Isonicotinamide
Isonicotinamide structure
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Common Name | Isonicotinamide | ||
|---|---|---|---|---|
| CAS Number | 1453-82-3 | Molecular Weight | 122.13 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 334.4±15.0 °C at 760 mmHg | |
| Molecular Formula | C6H6N2O | Melting Point | 155-157 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 156.0±20.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma.
Br. J. Cancer 111(3) , 477-85, (2014) Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angiogenesis, which is regulated by VEGF-A, itself alternativel... |
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[Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy.
J. Inorg. Biochem. 140 , 236-44, (2014) Tuberculosis has re-emerged as a worldwide threat, which has motivated the development of new drugs. The antituberculosis complex Na3[Fe(CN)5(isoniazid)] (IQG607) in particular is of interest on account of its ability to overcome resistance. IQG607 has the po... |
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Measuring induction times and crystal nucleation rates.
Faraday Discuss. 179 , 199-214, (2015) A large variation is observed in induction times measured under equal conditions in 1 ml solutions. Ruling out experimental errors, this variation originates from the nucleation process. The induction time distribution is explained by the stochastic nature of... |
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A novel strategy for pharmaceutical cocrystal generation without knowledge of stoichiometric ratio: myricetin cocrystals and a ternary phase diagram.
Pharm. Res. 32(1) , 47-60, (2015) To develop a streamlined strategy for pharmaceutical cocrystal preparation without knowledge of the stoichiometric ratio by preparing and characterizing the cocrystals of myricetin (MYR) with four cocrystal coformers (CCF).An approach based on the phase solub... |
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Zero-, one- and two-dimensional hydrogen-bonded structures in the 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid with the monocyclic heteroaromatic Lewis bases 2-aminopyrimidine, nicotinamide and isonicotinamide.
Acta Crystallogr. C 65(Pt 3) , o103-7, (2009) The structures of the anhydrous 1:1 proton-transfer compounds of 4,5-dichlorophthalic acid (DCPA) with the monocyclic heteroaromatic Lewis bases 2-aminopyrimidine, 3-(aminocarbonyl)pyridine (nicotinamide) and 4-(aminocarbonyl)pyridine (isonicotinamide), namel... |
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Cocrystals of quercetin with improved solubility and oral bioavailability.
Mol. Pharm. 8(5) , 1867-76, (2011) Flavonoids have been studied extensively due to the observation that diets rich in these compounds are associated with lower incidences of many diseases. One of the most studied flavonoids, quercetin, is also the most abundant of these compounds in the plant ... |
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Chiral carboxylic acids and their effects on melting-point behaviour in co-crystals with isonicotinamide.
Acta Crystallogr. B 64(Pt 6) , 780-90, (2008) The crystal structures of co-crystals of two systems of chiral carboxylic acids, optically active and racemic 2-phenylpropionic acid and 2-phenylbutyric acid, with isonicotinamide are reported to investigate the effects of the chirality of the chiral carboxyl... |
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Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models.
Pharmacol. Biochem. Behav. 99(4) , 782-8, (2011) Although there is evidence for the anti-inflammatory activity of nicotinamide, there is no evaluation of its effects in models of nociceptive and inflammatory pain. In addition, there is no information about the potential anti-inflammatory and antinociceptive... |
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The amide rotational barrier in isonicotinamide: Dynamic NMR and ab initio studies.
J. Phys. Chem. A 109(6) , 1152-8, (2005) We report use of dynamic nuclear magnetic resonance (NMR) to measure the amide rotational barrier in isonicotinamide. A significant challenge to obtaining good transition rates from dynamic NMR data is suppression of errors due to inherent line widths associa... |
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Molecular structure, vibrational spectra, quantum chemical calculations and photochemistry of picolinamide and isonicotinamide isolated in cryogenic inert matrixes and in the neat low-temperature solid phases.
J. Phys. Chem. A 112(1) , 45-57, (2008) Picolinamide (PA) and isonicotinamide (INA), two structural isomers of pyridinecarboxamide, have been investigated by matrix isolation and low-temperature solid-state infrared spectroscopy, combined with UV (lambda > 235 nm) photoexcitation and density functi... |