(3R,4S,5S,6S)-1-Aza-5-(t-butyldimethylsilyloxymethyl)-4-hydroxy-6-isopropyl-3-methyl-7-oxabicyclo[3.3.0]-octan-2-one

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Names

[ CAS No. ]:
145451-95-2

[ Name ]:
(3R,4S,5S,6S)-1-Aza-5-(t-butyldimethylsilyloxymethyl)-4-hydroxy-6-isopropyl-3-methyl-7-oxabicyclo[3.3.0]-octan-2-one

Chemical & Physical Properties

[ Density]:
1.064g/cm3

[ Boiling Point ]:
438.025ºC at 760 mmHg

[ Molecular Formula ]:
C17H33NO4Si

[ Molecular Weight ]:
343.53400

[ Flash Point ]:
218.71ºC

[ Exact Mass ]:
343.21800

[ PSA ]:
59.00000

[ LogP ]:
2.53640

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.496

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • tert-Butyldimethylsilyl chloride
  • METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE
  • methyl (2R,4R)-3-benzyl-2-tert-butyl-4-[(1S)-1-hydroxy-2-methylpropyl]-1,3-oxazolidine-4-carboxylate
  • (4R,5S)-N-Benzyl-4-(t-butyldimethylsilyloxymethyl)-4-hydroxymethyl-5-isopropyloxazoladine
  • methyl (4R,5S)-3-benzyl-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-propan-2-yl-1,3-oxazolidine-4-carboxylate
  • (2R,3S)-methyl 3-((4S,5S)-3-benzyl-4-(((tert-butyldimethylsilyl)oxy)methyl)-5-isopropyloxazolidin-4-yl)-3-hydroxy-2-methylpropanoate

DownStream

  • Omuralide
  • (3R,4S,5R,6S)-1-AZA-4-HYDROXY-5-HYDROXYMETHYL-6-ISOPROPYL-3-METHYL-7-OXABICYCL[3.3.0]OCTAN-2-ONE
  • (3R,4S)-(-)-1-BENZYL-3,4-PYRROLIDINDIOL