Proline

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Names

[ CAS No. ]:
147-85-3

[ Name ]:
Proline

[Synonym ]:
(-)-Proline
BYL719
Proline
Proline, L-
(-)-(S)-proline
(2S)-proline
pyrrolidine-2-carbonic acid
(2S)-2-Pyrrolidinecarboxylic acid
(S)-2-Carboxypyrrolidine
(-)-2-Pyrrolidinecarboxylic acid
2-Pyrrolidinecarboxylic acid
(−)-proline
(S)-proline
EINECS 210-189-3
2-Pyrrolidinecarboxylicacid
L(-)-Proline
(2S)-pyrrolidine-2-carboxylic acid
MFCD00064318
(−)-2-pyrrolidinecarboxylic acid
(−)-(S)-proline
(S)-(-)-Pyrrolidine-2-carboxylic acid
L-a-Pyrrolidinecarboxylic Acid
(S)-(-)-Proline
(l)-proline
l-Pro
QCR-1
(S)-Pyrrolidine-2-carboxylic acid,L-Proline
EINECS 205-702-2
L-(-)-proline
L-pyrrolidine-2-carboxylic acid
2-Pyrrolidinecarboxylic acid, (S)-
(S)-Pyrrolidine-2-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
252.2±33.0 °C at 760 mmHg

[ Melting Point ]:
228 °C (dec.)(lit.)

[ Molecular Formula ]:
C5H9NO2

[ Molecular Weight ]:
115.131

[ Flash Point ]:
106.3±25.4 °C

[ Exact Mass ]:
115.063332

[ PSA ]:
49.33000

[ LogP ]:
-0.57

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.487

[ Water Solubility ]:
soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TW3584000
CHEMICAL NAME :
Proline, L-
CAS REGISTRY NUMBER :
147-85-3
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H9-N-O2
MOLECULAR WEIGHT :
115.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81957 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81957 No. of Facilities: 762 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 18391 (estimated) No. of Female Employees: 13943 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TW3584000

[ HS Code ]:
2933990090

Synthetic Route

Precursor & DownStream

Precursor

  • Z-Pro-OH
  • (3R,6S,1'RS)-3-(methoxycarbonylcyanomethyl)-1,6-trimethylene-2,5-piperazinedione
  • Boc-L-Proline
  • (S)-1-ALLYLPYRROLIDINE-2-CARBOXYLIC ACID
  • H-D-Pro-OH
  • Poc-Pro-OH
  • (S)-1-((ALLYLOXY)CARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID
  • Boc-Pyr-OtBu
  • L-Prolinamide

DownStream

  • N-(3,5-Dinitrobenzoyl)-L-proline
  • (R)-1-BENZYL-3-AMINOPYRROLE-2,5-DIONE
  • (S)-1-((ALLYLOXY)CARBONYL)PYRROLIDINE-2-CARBOXYLIC ACID
  • H-N-Me-Pro-OH
  • 1-(3-MORPHOLIN-4-YLPHENYL)ETHANONE
  • 1-Benzyl-L-proline
  • (S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate
  • (S)-Pyrrolidine-2-carboxylic acid ethyl ester hydrochloride
  • Z-Pro-ONp
  • 1,3-diazabicyclo[3.3.0]octane-2,4-dione

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • proline
  • Proline
  • Proline
  • proline
  • L-proline
  • D-proline
  • Ethyl 2-[(2-phenoxyethyl)amino]propanoate
  • Acetic acid, 2-[(2-methoxy-2-oxoethyl)sulfonyl]-, 1-methylethyl ester
  • butyl 2-(3-amino-1H-pyrazol-1-yl)acetate
  • 3-(2-Benzylphenoxy)butan-2-one
  • Ethanone, 1-(3-bromophenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]-
  • Ethyl 4-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-3-oxobutanoate
  • 1-(4-Bromophenoxy)-3,3-dimethyl-2-butanone
  • 1-(3-Bromophenoxy)-3,3-dimethylbutan-2-one
  • 1-(1-Naphthalenyl)-2-phenoxyethanone
  • 3-(4-Amino-3-methyl-5-nitro-phenyl)-2-oxo-propionic acid