17-β-ESTRADIOL 3-METHYL ETHER

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Names

[ CAS No. ]:
1474-53-9

[ Name ]:
17-β-ESTRADIOL 3-METHYL ETHER

[Synonym ]:
3-methoxy-14-acetoxydibenz<a,j>anthracene
3-Methoxyestriol

Chemical & Physical Properties

[ Density]:
1.185g/cm3

[ Boiling Point ]:
450.8ºC at 760mmHg

[ Molecular Formula ]:
C19H26O3

[ Molecular Weight ]:
302.40800

[ Flash Point ]:
226.4ºC

[ Exact Mass ]:
302.18800

[ PSA ]:
49.69000

[ LogP ]:
2.88300

[ Vapour Pressure ]:
6.48E-09mmHg at 25°C

[ Index of Refraction ]:
1.588

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KG7540000
CHEMICAL NAME :
Estra-1,3,5(10)-triene-16-alpha,17-beta-diol, 3-methoxy-
CAS REGISTRY NUMBER :
1474-53-9
LAST UPDATED :
199304
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H26-O3
MOLECULAR WEIGHT :
302.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
5600 ug/kg
SEX/DURATION :
male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 15,16,1977

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
40

[ Safety Phrases ]:
36/37

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Estriol
  • Dimethyl sulfate
  • Estra-1,3,5(10)-trien-16-one,17-hydroxy-3-methoxy-, (17b)-
  • diazomethane
  • Tetramethylammonium hydroxide
  • Ethanol
  • acetic acid
  • Isopropanol

DownStream

  • Estra-1,3,5(10)-trien-17-one,3-methoxy-, oxime (7CI,8CI,9CI)
  • Estriol
  • Estrone 3-methyl ether

Related Compounds

  • 17-β-estradiol 3-phosphate 17-acetate
  • 17-(TRIFLUOROVINYL)-17-B-ESTRADIOL 3-METHYL ETHER
  • 17 beta-(arylazido-beta-alanine)estradiol-3-methyl ether
  • 1,3,5(10)-ESTRATRIEN-17-α-METHYL-3,17-β-DIOL 3-METHYL ETHER
  • 17-O-Acetyl-3-O-methyl-oestra-1,3,5(10),16-tetraen-3,17β-diol od. Oestron-17-enol-acetat-3-methylether
  • Estra-1,3,5(10)-trien-17-ol,3-methoxy-, (17b)-
  • 1-((4-bromobenzyl)thio)-4-butylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
  • tert-butyl (2E)-3-(3,4-dichlorophenyl)prop-2-enoate
  • 2-(2,4-Dihydroxyphenyl)acetaldehyde
  • 1-(m-Tolylsulfonyl)-1H-benzo[d]imidazole
  • 2-Amino-2-[4-(pyrrolidin-1-YL)phenyl]ethan-1-OL
  • 1-(2-Hydroxy-5-methylphenyl)prop-2-en-1-one
  • 5-Bromo-2,3,4-trifluorophenylacetic acid
  • 2-(3-methoxyphenyl)-4-(3-phenyl-1,2,4-oxadiazol-5-yl)isoquinolin-1(2H)-one
  • 2-Chloro-5-dimethylaminobenzoic acid
  • (1R,5S)-6-Methyl-3,6-diazabicyclo[3.2.1]octane
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