Pregabalin

Suppliers

Names

[ Name ]:
Pregabalin

[Synonym ]:
(S)-3-Aminomethyl-5-methyl-hexanoic acid
EINECS 200-659-6
(S)-3-(Aminomethyl)-5-methylhexanoic acid CI-1008 PD-144723
PREDNISOLONESODIUMPHOSPHATE
Hexanoic acid, 3-(aminomethyl)-5-methyl-, (3S)-
Pregablin
(S)-3-(Aminomethyl)-5-methylhexanoic acid
Pregabalin
Lyrica
prégabaline
(S)-3-Isobutyl GABA
MFCD00917044
(S)-(+)-3-aminomethyl-5-methylhexanoic acid
(3S)-3-(Aminomethyl)-5-methylhexanoic acid

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
274.0±23.0 °C at 760 mmHg

[ Melting Point ]:
194-196ºC

[ Molecular Formula ]:
C₈H₁₇NO₂

[ Molecular Weight ]:
159.226

[ Flash Point ]:
119.5±22.6 °C

[ Exact Mass ]:
159.125931

[ PSA ]:
63.32000

[ LogP ]:
1.12

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.465

[ Storage condition ]:
Store at RT

Safety Information

[ Symbol ]:

GHS05, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318-H361

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn,T,F

[ Risk Phrases ]:
63-48/22-39/23/24/25-23/24/25-11

[ Safety Phrases ]:
22-36/37-45-16-7

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(3S)-3-Cyano-5-methyl-Hexanoic acid ethyl ester
(S)-pregabalin-(-)-O,O'-dibenzoyl-L-tartrate
(S)-3-(aminomethyl)-5-methyl-N-((S)-1-phenylethyl)hexanamide
3-(Aminomethyl)-5-methylhexanoic acid
(3R)-3-(2-Amino-2-oxoethyl)-5-methylhexanoic acid

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 990 , 23-30, (2015)

Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewag...

Effect of the gastrointestinal prokinetic agent erythromycin on the pharmacokinetics of pregabalin controlled-release in healthy individuals: a phase I, randomized crossover trial.

Clin. Drug Investig. 35(5) , 299-305, (2015)

The controlled-release (CR) formulation of pregabalin is designed to remain in the stomach for a prolonged period while slowly releasing pregabalin for absorption in the small intestine. This study ev...

Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015)

Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix c...

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