Tyrphostin AG 879

Suppliers

Names

[ Name ]:
Tyrphostin AG 879

[Synonym ]:
AG 879
2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-
BMK1-D4
2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)-
(2E)-2-Cyano-3-[4-hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]-2-propenethioamide
2-Propenethioamide,3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-,(2E)
Lopac-T-2067
Tyrphostin AG 879
(2E)-2-Cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
432.7±55.0 °C at 760 mmHg

[ Melting Point ]:
232 °C

[ Molecular Formula ]:
C₁₈H₂₄N₂OS

[ Molecular Weight ]:
316.461

[ Flash Point ]:
215.5±31.5 °C

[ Exact Mass ]:
316.160919

[ PSA ]:
102.13000

[ LogP ]:
4.76

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Storage condition ]:
Store at -20°C

[ Water Solubility ]:
DMSO: at 26 mg/mlsoluble

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay.

Reproduction 136 , 459-69, (2008)

The first morphological sign of testicular differentiation is the formation of testis cords. Prior to cord formation, newly specified Sertoli cells establish adhesive junctions, and condensation of so...

Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.

Mol. Nutr. Food. Res. 52(7) , 815-22, (2008)

In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulv...

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.

Cancer Biol. Ther. 3(1) , 96-101, (2004)

AG 879 has been widely used as a Tyr kinase inhibitor specific for ErbB2 and FLK-1, a VEGF receptor. The IC(50) for both ErbB2 and FLK-1 is around 1 microM. AG 879, in combination of PP1 (an inhibitor...

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3-(1-ethynylcyclopropyl)-1H-pyrrolo[2,3-b]pyridine
(1R)-3-amino-1-[5-(4-methylphenyl)furan-2-yl]propan-1-ol
4-chloro-1-methyl-5-[(3-methylazetidin-3-yl)oxy]-1H-imidazole
1-(1-ethyl-1H-imidazol-2-yl)-3-oxocyclobutane-1-carboxylic acid
3-{Imidazo[1,2-a]pyridin-3-yl}-2,2-dimethylcyclopropane-1-carboxylic acid
2-(4-chloro-1-ethyl-1H-imidazol-5-yl)prop-2-enoic acid
1-(4,4-Dimethylcyclohexyl)-3-oxocyclobutane-1-carbonitrile
(2S)-1-[1-(2-methylpropyl)-1H-pyrazol-3-yl]propan-2-ol
rac-3-[(1R,2S)-2-aminocyclopropyl]-4-bromobenzonitrile
O-[1-(1-methyl-1H-indol-5-yl)ethyl]hydroxylamine

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