Tyrphostin AG 879
Tyrphostin AG 879 structure
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Common Name | Tyrphostin AG 879 | ||
|---|---|---|---|---|
| CAS Number | 148741-30-4 | Molecular Weight | 316.461 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 432.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H24N2OS | Melting Point | 232 °C | |
| MSDS | Chinese USA | Flash Point | 215.5±31.5 °C | |
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Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay.
Reproduction 136 , 459-69, (2008) The first morphological sign of testicular differentiation is the formation of testis cords. Prior to cord formation, newly specified Sertoli cells establish adhesive junctions, and condensation of somatic cells along the surface epithelium of the genital rid... |
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Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.
Mol. Nutr. Food. Res. 52(7) , 815-22, (2008) In the present study, delphinidin was found to suppress the phosphorylation of the epidermal growth factor receptor (EGFR) within human tumour cells (human colon carcinoma cell line (HT29), human vulva carcinoma cell line (A431)), albeit less effective than t... |
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The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.
Cancer Biol. Ther. 3(1) , 96-101, (2004) AG 879 has been widely used as a Tyr kinase inhibitor specific for ErbB2 and FLK-1, a VEGF receptor. The IC(50) for both ErbB2 and FLK-1 is around 1 microM. AG 879, in combination of PP1 (an inhibitor specific for Src kinase family), suppresses almost complet... |
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Novel actions of tyrphostin AG 879: inhibition of RAF-1 and HER-2 expression combined with strong antitumoral effects on breast cancer cells.
Cell. Mol. Life Sci. 61(19-20) , 2624-31, (2004) Binding of growth factors to cell surface receptors activates protein tyrosine kinases (PTKs) that initiate cascades of downstream signaling events including the mitogen-activated protein (MAP) kinase cascade. This study reports that the PTK inhibitor AG 879 ... |