U 74389G maleate

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Names

[ Name ]:
U 74389G maleate

[Synonym ]:
MFCD01074991
Pregna-1,4,9(11)-triene-3,20-dione, 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-, (2Z)-2-butenedioate (1:1)
21-{4-[2,6-Di(pyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-but-2-enedioate (1:1)
21-{4-[2,6-Di(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-2-butenedioate (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
811.6ºC at 760 mmHg

[ Molecular Formula ]:
C₄₁H₅₄N₆O₆

[ Molecular Weight ]:
726.904

[ Flash Point ]:
444.6ºC

[ Exact Mass ]:
726.410461

[ PSA ]:
147.48000

[ LogP ]:
5.05700

[ Vapour Pressure ]:
2.12E-26mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.

Neuropharmacology 99 , 422-31, (2015)

Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat l...

Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications.

Hepatology 34(5) , 990-9, (2001)

Portal hypertensive (PHT) gastropathy is a frequent, serious complication of liver cirrhosis. PHT gastric mucosa has numerous abnormalities such as reduced mucosal potential differences, reduced surfa...

Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants.

Circulation 92 , 238, (1995)

Transition metals such as copper are known to initiate free radical formation and lipid peroxidation. Recent reports suggest that intracellular reactive oxygen intermediates can induce the transcripti...

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