Bexarotene

Suppliers

Names

[ CAS No. ]:
153559-49-0

[ Name ]:
Bexarotene

[Synonym ]:
Targretin
Bexarotene
4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
LG 69
4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)vinyl]benzoic acid
Lg 1069
4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
Targretyn
Bexaroten
Targret
Benzoic acid, 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-
4-[1-(3,5,5,8,8-Pentamethyl-2-5,8-dihydronaphthyl)vinyl]benzoic acid
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
LGD1069

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
489.7±44.0 °C at 760 mmHg

[ Melting Point ]:
230-231ºC

[ Molecular Formula ]:
C24H28O2

[ Molecular Weight ]:
348.478

[ Flash Point ]:
229.5±23.1 °C

[ Exact Mass ]:
348.208923

[ PSA ]:
37.30000

[ LogP ]:
8.55

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.556

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoate
  • 1,1,4,4,6-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE
  • Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate
  • 2,5-Dimethyl-2,5-hexanediol
  • bexarotene ethyl ester
  • 2,5-Dichloro-2,5-dimethylhexane
  • 6-BROMO-1,1,4,4,7-PENTAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE
  • 2(1H)-Naphthalenone, 3,4-dihydro-1,1,4,4,7-pentamethyl-
  • Toluene
  • 1,1,4,4,6-pentamethyl-1,4-dihydronaphthalene

DownStream

Articles

Retinoids Bias Integrin Expression and Function in Cutaneous T-Cell Lymphoma.

J. Invest. Dermatol. 135 , 2102-8, (2015)

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of malignancies characterized by accumulation of malignant T-cells within the skin. Retinoids, metabolic derivatives, and synthetic analogs of...

RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.

Neurobiol. Dis. 82 , 132-40, (2015)

We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ level...

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.

J. Clin. Invest. 125(2) , 809-23, (2015)

Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogene...


More Articles

Related Compounds

  • Bexarotene-d3
  • Bexarotene D4
  • Bexarotene-13C4
  • 7-Hydroxy Bexarotene
  • 6-hydroxy Bexarotene
  • bexarotene ethyl ester
  • tert-butyl N-{5-[(3S)-3-aminobutyl]-2-hydroxy-3-methoxyphenyl}carbamate
  • 5-(3-Ethoxy-4-methoxyphenyl)-1,3-oxazolidin-2-one
  • 1-(1,5-dimethyl-1H-pyrazol-4-yl)-3-oxocyclobutane-1-carbonitrile
  • 2-Amino-2-(1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}cyclopropyl)acetic acid
  • methyl 5-(1-bromo-2-methylpropan-2-yl)-1-methyl-1H-pyrazole-4-carboxylate
  • Methyl 3-amino-2-(3,5-difluoro-2-hydroxyphenyl)propanoate
  • 2-(1H-indazol-7-yl)-2-methylpropanal
  • 4-methoxy-N,N-dimethyl-5-[(2S)-oxiran-2-yl]-1,3-thiazol-2-amine
  • 1-(3-bromo-1-methyl-1H-pyrazol-5-yl)ethane-1,2-diol
  • (2S)-1-(1-methylcyclohexyl)propan-2-amine
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