LG100268

Names

[ CAS No. ]:
153559-76-3

[ Name ]:
LG100268

[Synonym ]:
AmbkkkkK580
BIDD:PXR0022

Chemical & Physical Properties

[ Density]:
1.115g/cm3

[ Boiling Point ]:
487ºC at 760mmHg

[ Melting Point ]:
275-277ºC

[ Molecular Formula ]:
C₂₄H₂₉NO₂

[ Molecular Weight ]:
363.49300

[ Flash Point ]:
248.3ºC

[ Exact Mass ]:
363.22000

[ PSA ]:
50.19000

[ LogP ]:
5.51710

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.577

[ Storage condition ]:
-20°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5921500

CHEMICAL NAME :: 3-Pyridinecarboxylic acid, 6-(1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naph thalenyl) cyclopropyl)-

CAS REGISTRY NUMBER :: 153559-76-3

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21780 ug/kg/3D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Effect on specific coenzyme - CoA

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,264,1996

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.

Genes Dev. 28(14) , 1562-77, (2014)

RXR signaling is predicted to have a major impact in macrophages, but neither the biological consequence nor the genomic basis of its ligand activation is known. Comprehensive genome-wide studies were...

Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.

Chem. Res. Toxicol. 28 , 1156-66, (2015)

Organotins are members of the environmental obesogen class of contaminants because they activate peroxisome proliferator-activated receptor γ (PPARγ), the essential regulator of adipogenesis. Exposure...

Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells.

Mol. Endocrinol. 24 , 2218-2231, (2010)

Retinoid X receptors (RXRs) are heterodimerization partners for many nuclear receptors and also act as homodimers. Heterodimers formed by RXR and a nonpermissive partner, e.g. retinoic acid receptor (...

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