LG100268
LG100268 structure
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Common Name | LG100268 | ||
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| CAS Number | 153559-76-3 | Molecular Weight | 363.49300 | |
| Density | 1.115g/cm3 | Boiling Point | 487ºC at 760mmHg | |
| Molecular Formula | C24H29NO2 | Melting Point | 275-277ºC | |
| MSDS | USA | Flash Point | 248.3ºC | |
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The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.
Genes Dev. 28(14) , 1562-77, (2014) RXR signaling is predicted to have a major impact in macrophages, but neither the biological consequence nor the genomic basis of its ligand activation is known. Comprehensive genome-wide studies were carried out to map liganded RXR-mediated transcriptional c... |
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Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.
Chem. Res. Toxicol. 28 , 1156-66, (2015) Organotins are members of the environmental obesogen class of contaminants because they activate peroxisome proliferator-activated receptor γ (PPARγ), the essential regulator of adipogenesis. Exposure to thiazolidinediones (PPARγ ligands used to treat type 2 ... |
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Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells.
Mol. Endocrinol. 24 , 2218-2231, (2010) Retinoid X receptors (RXRs) are heterodimerization partners for many nuclear receptors and also act as homodimers. Heterodimers formed by RXR and a nonpermissive partner, e.g. retinoic acid receptor (RAR) and vitamin D receptor (VDR), can be activated only by... |
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Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin.
PLoS ONE 8 , e62643, (2013) Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases. The present study used topical application o... |
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Rosiglitazone activation of PPARgamma suppresses fractalkine signaling.
J. Mol. Endocrinol. 44 , 135-42, (2010) The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is a key transcriptional regulator of both lipid metabolism and inflammation. The importance of PPARgamma is accentuated by the widespread use of synthetic PPARgamma agonists, t... |