3-Phenyl-1H-pyrazol-5-amine

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Names

[ CAS No. ]:
1572-10-7

[ Name ]:
3-Phenyl-1H-pyrazol-5-amine

[Synonym ]:
MFCD00191749
1H-Pyrazol-3-amine, 5-phenyl-
1H-Pyrazol-5-amine, 3-phenyl-
3-Phenyl-1H-pyrazol-5-amine
3-Amino-5-phenylpyrazole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
442.3±33.0 °C at 760 mmHg

[ Melting Point ]:
118-121ºC

[ Molecular Formula ]:
C9H9N3

[ Molecular Weight ]:
159.19

[ Flash Point ]:
251.5±12.6 °C

[ Exact Mass ]:
159.079651

[ PSA ]:
54.70000

[ LogP ]:
1.34

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.663

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ6109000
CHEMICAL NAME :
Pyrazole, 5-amino-3-phenyl-
CAS REGISTRY NUMBER :
1572-10-7
BEILSTEIN REFERENCE NO. :
0004947
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H9-N3
MOLECULAR WEIGHT :
159.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
630 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 27,295,1964

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UQ6109000

Precursor & DownStream

Precursor

  • 3-Oxo-3-phenylpropanenitrile
  • 3-amino-5-phenylisothiazole
  • 4-bromo-3-hydrazinyl-5-phenylisothiazole
  • METHYL 6-(TRIFLUOROMETHYL)-1H-INDOL-5-YL ETHER
  • Methyl benzoate

DownStream

  • 1,2-dimethyl-3-phenyl-5-salicyloylimino-3-pyrazoline
  • Salicylic acid
  • 2,6-diphenyl-1H-pyrazolo[1,5-a]pyrimidine-5,7-dione
  • Ethyl 7-methyl-2-phenylpyrazolo[1,5-a]pyrimidine-6-carboxylate
  • 5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-7(4h)-one
  • 2,8-diphenyl-1,4,5,9-tetrazabicyclo[4.3.0]nona-2,4,6,8-tetraene
  • 5,7-Dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine

Articles

Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells.

ChemMedChem 7(8) , 1453-64, (2012)

A library of new anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates were designed, synthesized, and evaluated for their anticancer activity in cervical cancer cells such as HeLa and SiHa that possess...

Botulinum neurotoxin serotype A inhibitors: small-molecule mercaptoacetamide analogs.

Bioorg. Med. Chem. 17(8) , 3072-9, (2009)

Botulinum neurotoxin elicits its paralytic activity through a zinc-dependant metalloprotease that cleaves proteins involved in neurotransmitter release. Currently, no drugs are available to reverse th...

An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.

Org. Lett. 11(22) , 5214-7, (2009)

A mild one-step synthetic method to access privileged heterobiaryl pyrazolo[3,4-b]pyridines from indole-3-carboxaldehyde derivatives and a variety of aminopyrazoles has been developed. This novel meth...


More Articles

Related Compounds

  • 3-PHENYL-1H-PYRAZOL-5-AMINE
  • 4-BROMO-3-PHENYL-1H-PYRAZOL-5-AMINE
  • N-ethyl-3-phenyl-1H-pyrazol-5-amine
  • 1-Ethyl-3-phenyl-1H-pyrazol-5-amine
  • 1-Benzyl-3-phenyl-1H-pyrazol-5-amine
  • 1-Methyl-3-phenyl-1H-pyrazol-5-amine
  • benzyl N-[4-(furan-2-yl)-4-hydroxybutan-2-yl]carbamate
  • benzyl N-{2-[(furan-2-yl)methyl]-3-hydroxypropyl}carbamate
  • 1-Benzyl 3-methyl 3-(prop-2-en-1-yl)azetidine-1,3-dicarboxylate
  • 2-(4-bromothiophen-2-yl)-2-{2,2,2-trifluoro-N-[(oxolan-2-yl)methyl]acetamido}acetic acid
  • [3-(Trifluoromethyl)-2-oxabicyclo[2.1.1]hexan-1-yl]methyl 4-methylbenzene-1-sulfonate
  • benzyl N-[1-(3-bromophenyl)-4,4,4-trifluorobutan-2-yl]carbamate
  • benzyl N-[4-(3-bromo-4-fluorophenoxy)phenyl]carbamate
  • benzyl N-[3-bromo-4-(4-fluorophenoxy)phenyl]carbamate
  • tert-butyl N-{3-tert-butyl-1-iodoimidazo[1,5-a]pyrazin-8-yl}carbamate
  • tert-butyl N-(4-bromo-9,10-dioxo-9,10-dihydroanthracen-1-yl)-N-methylcarbamate
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