2,2',5,5'-Tetrachloro-4,4'-biphenyldiamine

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Names

[ CAS No. ]:
15721-02-5

[ Name ]:
2,2',5,5'-Tetrachloro-4,4'-biphenyldiamine

[Synonym ]:
2,2',5,5'-Tetrachloro-4,4'-biphenyldiamine
4,4'-Diamino-2,2',5,5'-tetrachlorobiphenyl
EINECS 239-815-3
2,2′,5,5′-Tetrachlorobenzidine
MFCD00043918
[1,1'-Biphenyl]-4,4'-diamine, 2,2',5,5'-tetrachloro-
4-(4-amino-2,5-dichlorophenyl)-2,5-dichloroaniline
2,2',5,5'-Tetrachlorobiphenyl-4,4'-diamine

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
408.2±40.0 °C at 760 mmHg

[ Melting Point ]:
135-140 °C(lit.)

[ Molecular Formula ]:
C12H8Cl4N2

[ Molecular Weight ]:
322.017

[ Flash Point ]:
200.7±27.3 °C

[ Exact Mass ]:
319.944153

[ PSA ]:
52.04000

[ LogP ]:
4.83

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.687

[ Storage condition ]:
-70°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD1751000
CHEMICAL NAME :
Benzidine, 2,2',5,5'-tetrachloro-
CAS REGISTRY NUMBER :
15721-02-5
BEILSTEIN REFERENCE NO. :
3364286
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H8-Cl4-N2
MOLECULAR WEIGHT :
322.02
WISWESSER LINE NOTATION :
ZR BG EG DR DZ CG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
54 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - lymphoma, including Hodgkin's disease
REFERENCE :
JMEJAS Jikeikai Medical Journal. (Jikei Univ. School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1954- Volume(issue)/page/year: 25,123,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
36 mg/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - lymphoma, including Hodgkin's disease
REFERENCE :
JMEJAS Jikeikai Medical Journal. (Jikei Univ. School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1954- Volume(issue)/page/year: 25,123,1978
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 gm/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 gm/kg/43W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE :
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,141,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

Safety Information

[ Hazard Codes ]:
T

[ Risk Phrases ]:
61

[ Safety Phrases ]:
53-45

[ WGK Germany ]:
3

[ RTECS ]:
DD1751000

[ HS Code ]:
2921590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2-bis(2,5-dichlorophenyl)hydrazine
  • N-(4-amino-2,5-dichlorophenyl)acetamide
  • Hydrochloric acid

DownStream

  • 2,2',3,3',5,5'-hexachlorobiphenyl
  • 2,2',5,5'-PCB
  • OCTACHLOROBIPHENYL
  • PCB-153

Customs

[ HS Code ]: 2921590090

[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 2,2',5,5'-Tetrachloro-4,4'-diisocyanato-1,1'-biphenyl
  • 4-[(4-amino-2,5-dichlorophenyl)methyl]-2,5-dichloroaniline
  • 1,4-dichloro-2-(2,5-dichloro-4-methylsulfanylphenyl)-5-methylsulfanylbenzene
  • 2,2,5,5-Tetrakis(hydroxymethyl)-cyclopentanone tetranitrate
  • 4,4'-bis(methylsulfonyl)-2,2',5,5'-tetrachlorobiphenyl
  • 4,4-DIAMINO-2,2'-DICHLORODIPHENYL DISULFIDE