3-(4-Chlorophenyl)acrylic acid

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Names

[ CAS No. ]:
1615-02-7

[ Name ]:
3-(4-Chlorophenyl)acrylic acid

[Synonym ]:
p-chloro-cinnamicaci
2-Propenoic acid, 3-(4-chlorophenyl)-, (2E)-
4-Chlorociamic acid
4-Chlorocinncmic Acid
trans-3-(4-Chlorophenyl)propenoic acid
(2E)-3-(4-Chlorophenyl)acrylic acid
PARA-CHLOROCINNAMICACID
MFCD00004396
3-(4-Chlorophenyl)acrylic acid
Cinnamic acid,p-chloro
p-Chlorocinnamic acid
trans-4-chlorocinnamic acid
EINECS 216-564-8
RARECHEM BK HC T318
4-ChlorocinnaMic Acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
325.3±17.0 °C at 760 mmHg

[ Melting Point ]:
248-250 °C(lit.)

[ Molecular Formula ]:
C9H7ClO2

[ Molecular Weight ]:
182.60

[ Flash Point ]:
150.5±20.9 °C

[ Exact Mass ]:
182.013458

[ PSA ]:
37.30000

[ LogP ]:
2.94

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.628

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD8490000
CHEMICAL NAME :
Cinnamic acid, p-chloro-
CAS REGISTRY NUMBER :
1615-02-7
LAST UPDATED :
199206
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H7-Cl-O2
MOLECULAR WEIGHT :
182.61
WISWESSER LINE NOTATION :
QV1U1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1622 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 23,714,1968
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>350 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - rigidity (including catalepsy)
REFERENCE :
IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,77,1987

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36-S28A

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GD8490000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Chloro-4-iodobenzene
  • Acrylic acid
  • 4-Chlorobenzaldehyde
  • acetic acid
  • Malonic acid
  • carbon monoxide
  • (E)-β-bromo-p-chlorostyrene
  • 4-Bromochlorobenzene
  • Cinnamic acid, p-chloro-, ethyl ester
  • Ethanoic anhydride

DownStream

  • 4-BROMO-7-CHLOROISOQUINOLIN-1(2H)-ONE
  • 3,3-Diphenylpropanoic acid
  • Methyl 3-phenylpropanoate
  • 3-(4-Chlorophenyl)propanoic acid
  • Hydrocinnamic acid
  • 1-(4-Chlorophenyl)ethanone
  • 3,6-Dichloro-1-benzothiophene-2-carbonyl chloride
  • 3-(4-chlorophenyl)-N-hydroxyprop-2-enamide
  • 4-Chlorophenylacetylene
  • 4-Chlorobenzaldehyde

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • (2E)-3-(4-Chlorophenyl)acrylic acid
  • 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID
  • (E)-2-phenyl-3-(4-chlorophenyl)acrylic acid
  • (E)-3-(4-Chlorophenyl)acrylic acid ethyl ester
  • (Z)-2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID
  • (Z)-2-BENZAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID
  • 1-(cyclopentylmethyl)-1H-1,2,3-benzotriazole-6-carbonitrile
  • 1-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-1H-benzo[d][1,2,3]triazole-6-carbonitrile
  • 5-(3-Methylbut-3-en-1-yl)-1,2,3,6-tetrahydropyridin-3-amine
  • 5-{6-Methyl-1,7-diazaspiro[4.5]decan-1-yl}pentanenitrile
  • O-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-methylpropyl}hydroxylamine
  • O-{[1-(2-chloro-6-fluorophenyl)cyclopropyl]methyl}hydroxylamine
  • 4-chloro-1-ethyl-5-(2-isocyanatoethyl)-1H-imidazole
  • 1-(1,1-Dioxidothietan-3-yl)-1H-benzo[d][1,2,3]triazole-5-carbonitrile
  • 6-Amino-5-(2-chloro-6-fluorophenyl)-2-(piperazin-1-yl)-3,4-dihydropyrimidin-4-one
  • (3-methyl-1-propyl-1H-pyrazol-4-yl)methyl methanesulfonate