3-(4-Chlorophenyl)acrylic acid

Modify Date: 2025-08-20 23:50:22

3-(4-Chlorophenyl)acrylic acid structure	Common Name	3-(4-Chlorophenyl)acrylic acid
	CAS Number	1615-02-7	Molecular Weight	182.60
	Density	1.3±0.1 g/cm3	Boiling Point	325.3±17.0 °C at 760 mmHg
	Molecular Formula	C₉H₇ClO₂	Melting Point	248-250 °C(lit.)
	MSDS	USA	Flash Point	150.5±20.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of 3-(4-Chlorophenyl)acrylic acid

4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth[1][2][3].

Name	4-Chlorocinnamic acid
Synonym	More Synonyms

Description	4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Cui Y, et al. Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. Int J Biol Macromol. 2017 Feb;95:1289-1297. [2]. Silva RHN, et al. Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives. Biomed Res Int. 2019 Apr 23;2019:3941242. [3]. Kátia Aparecida de Siqueira, et al. Isolation of 4-chlorocinnamic acid from Streptomyces griseocarneus R132, and its inhibition activity against sweet pepper postharvest anthracnose. Biocontrol Science and Technology. Volume 32, 2022-Issue 6

Description

4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth[1][2][3].

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Cui Y, et al. Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. Int J Biol Macromol. 2017 Feb;95:1289-1297.

[2]. Silva RHN, et al. Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives. Biomed Res Int. 2019 Apr 23;2019:3941242.

[3]. Kátia Aparecida de Siqueira, et al. Isolation of 4-chlorocinnamic acid from Streptomyces griseocarneus R132, and its inhibition activity against sweet pepper postharvest anthracnose. Biocontrol Science and Technology. Volume 32, 2022-Issue 6

Density	1.3±0.1 g/cm3
Boiling Point	325.3±17.0 °C at 760 mmHg
Melting Point	248-250 °C(lit.)
Molecular Formula	C₉H₇ClO₂
Molecular Weight	182.60
Flash Point	150.5±20.9 °C
Exact Mass	182.013458
PSA	37.30000
LogP	2.94
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.628
Storage condition	Room temperature.

3-(4-Chlorophenyl)acrylic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD8490000

CHEMICAL NAME :: Cinnamic acid, p-chloro-

CAS REGISTRY NUMBER :: 1615-02-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-Cl-O2

MOLECULAR WEIGHT :: 182.61

WISWESSER LINE NOTATION :: QV1U1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1622 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 23,714,1968

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >350 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - rigidity (including catalepsy)

REFERENCE :: IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,77,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S36-S28A
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GD8490000
HS Code	2916399090

Precursor 10
CAS#:637-87-6 1-Chloro-4-iodo... CAS#:79-10-7 Acrylic acid CAS#:104-88-1 4-Chlorobenzaldehyde CAS#:64-19-7 acetic acid
CAS#:141-82-2 Malonic acid CAS#:201230-82-2 carbon monoxide CAS#:66482-29-9 (E)-β-bromo-p-c... CAS#:106-39-8 4-Bromochlorobenzene
CAS#:24393-52-0 Cinnamic acid, ... CAS#:108-24-7 Ethanoic anhydride
DownStream 10
CAS#:1028252-13-2 4-BROMO-7-CHLOR... CAS#:606-83-7 3,3-Diphenylpro... CAS#:103-25-3 Methyl 3-phenyl... CAS#:2019-34-3 3-(4-Chlorophen...
CAS#:501-52-0 Hydrocinnamic acid CAS#:99-91-2 1-(4-Chlorophen... CAS#:34576-85-7 3,6-Dichloro-1-... CAS#:29900-76-3 3-(4-chlorophen...
CAS#:873-73-4 4-Chlorophenyla... CAS#:104-88-1 4-Chlorobenzaldehyde

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

p-chloro-cinnamicaci

2-Propenoic acid, 3-(4-chlorophenyl)-, (2E)-

4-Chlorociamic acid

4-Chlorocinncmic Acid

trans-3-(4-Chlorophenyl)propenoic acid

(2E)-3-(4-Chlorophenyl)acrylic acid

PARA-CHLOROCINNAMICACID

MFCD00004396

3-(4-Chlorophenyl)acrylic acid

Cinnamic acid,p-chloro

p-Chlorocinnamic acid

trans-4-chlorocinnamic acid

EINECS 216-564-8

RARECHEM BK HC T318

4-ChlorocinnaMic Acid

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China
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 3-(4-Chlorophenyl)acrylic acid
Price: ￥Inquiry/1kg ￥Inquiry/25kg ￥Inquiry/200kg
Purity: 99.0%
Delivery: 3 Day
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3-(4-Chlorophenyl)acrylic acid

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