1,4-Butane sultone

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Names

[ CAS No. ]:
1633-83-6

[ Name ]:
1,4-Butane sultone

[Synonym ]:
1,2-Oxathiane, 2,2-dioxide
oxathiane 2,2-dioxide
1,4-Butane sultone
EINECS 216-647-9
MFCD00006584
1,2-Oxathiane 2,2-dioxide
1,4-Butanesultone
1.4-Butane Sultone

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
299.9±9.0 °C at 760 mmHg

[ Melting Point ]:
12.5-15ºC

[ Molecular Formula ]:
C4H8O3S

[ Molecular Weight ]:
136.169

[ Flash Point ]:
135.2±18.7 °C

[ Exact Mass ]:
136.019409

[ PSA ]:
51.75000

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.471

[ Water Solubility ]:
54 g/L (20 ºC) decomposes

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP4300000
CHEMICAL NAME :
1,2-Oxathiane, 2,2-dioxide
CAS REGISTRY NUMBER :
1633-83-6
BEILSTEIN REFERENCE NO. :
0110588
LAST UPDATED :
199701
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C4-H8-O3-S
MOLECULAR WEIGHT :
136.18
WISWESSER LINE NOTATION :
T6OSWTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
138 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Reproductive - Tumorigenic effects - ovarian tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2280 mg/kg/76W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1680 mg/kg/42W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Embryo
DOSE/DURATION :
5 mg/L
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 19,642,1977

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H351

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R68

[ Safety Phrases ]:
S36/37-S45

[ RIDADR ]:
UN 2810

[ WGK Germany ]:
3

[ RTECS ]:
RP4300000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-MERCAPTO-1-BUTANOL
  • 4-Chloro-1-butylsulfonyl Chloride
  • 1-Chlorobutane
  • Benzenediazonium,2-methoxy-5-methyl-4-[2-(4-methyl-2-nitrophenyl)diazenyl]-
  • 4,4'-oxy-bis-butane-1-sulfonic acid
  • thf
  • 4-hydroxy-1-butanesulfonyl chloride
  • Butanol

DownStream

  • 4-aminobutane-1-sulfonic acid
  • Benzenediazonium,2-methoxy-5-methyl-4-[2-(4-methyl-2-nitrophenyl)diazenyl]-
  • 1-Butanesulfonic acid,4-hydroxy-, sodium salt (1:1)
  • 4-(2,3,3-Trimethyl-3H-indol-1-ium-1-yl)butane-1-sulfonate
  • 1,1,2-Trimethyl-3-(4-sulfobutyl)-1h-benz[e]indoliumhydroxide,innersalt
  • 4-[2-amino-5-[4-amino-3-(4-sulfobutoxy)phenyl]phenoxy]butane-1-sulfonic acid
  • 4-(1,1,2-trimethyl-2H-benzo[e]indol-3-yl)butane-1-sulfonic acid
  • 1-Hexanesulfonic acid
  • Triphenyl-(4-sulfo-butyl)-phosphonium inner salt
  • 4-(2-methylimidazol-1-yl)butane-1-sulfonic acid

Customs

[ HS Code ]: 2934991000

[ Summary ]:
2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Synthesis of alkylated potato starch derivatives and their potential in the aqueous solubilization of benzo[a]pyrene.

Carbohydr. Polym. 93(1) , 184-90, (2013)

For the development of renewable bioproducts able to solubilize organic persistent pollutant such as benzo[a]pyrene (BaP), modified potato starch was synthesized by alkylation. The addition of alkyl c...

Determination of the substituent distribution in O-sulfonylbutyl-(1-->4)-glucans.

Carbohydr. Res. 327(3) , 275-85, (2000)

A method has been developed to determine the distribution of substituents in the glucose units of sulfonylbutylethers of cyclomaltoheptaose (beta-cyclodextrin). This method involves hydrolysis of the ...

Formation of unexpected substitution patterns in sulfonylbutylation of cyclomaltoheptaose promoted by host-guest interaction.

Carbohydr. Res. 327(3) , 269-74, (2000)

The distribution of substituents in sulfonylbutylethers of cyclomaltoheptaose (beta-cyclodextrin) formed in aqueous medium has been determined by gas chromatography after hydrolysis and formation of t...


More Articles

Related Compounds

  • 1,4-butane sultone
  • 1,4-butane-d8-diamine
  • 1,4-butane-1,1,4,4-d4-diol
  • 1,4-BUTANE DIISOTHIOCYANATE
  • 1,3-oxathiane 3,3-dioxide
  • octafluoronaphtalene-1,4-sultone
  • 1-(2-bromo-4-chlorophenyl)-N-methylmethanesulfonamide
  • 1-(4-bromo-2-chlorophenyl)-N-methylmethanesulfonamide
  • 1-(3,4-dibromophenyl)-N-methylmethanesulfonamide
  • 1-cyclopropyl-N-methylethane-1-sulfonamide
  • 3-{[(Benzyloxy)carbonyl](5,5,5-trifluoropentyl)amino}propanoic acid
  • 6-(2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]sulfanyl}acetyl)-6-azaspiro[3.4]octane-8-carboxylic acid
  • 6-[2-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetyl]-6-azaspiro[3.4]octane-8-carboxylic acid
  • rac-6-[(1R,2S)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropanecarbonyl]-6-azaspiro[3.4]octane-8-carboxylic acid
  • 1-Bromo-2,2-dimethyl-5-(propan-2-yloxy)pentane
  • 3-(3-Chloro-2,2-dimethylpropyl)oxane
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