(R)-Ezetimibe

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Names

[ CAS No. ]:
163380-16-3

[ Name ]:
(R)-Ezetimibe

[Synonym ]:
1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-
(3’R)-Ezetimibe;(3R,4S)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone;EzetiMibe (3R)-IsoMer;(R)-EzetiMibe
Ezetimibe Impurity 2

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
654.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H21F2NO3

[ Molecular Weight ]:
409.425

[ Flash Point ]:
349.9±31.5 °C

[ Exact Mass ]:
409.148956

[ PSA ]:
60.77000

[ LogP ]:
3.26

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.624

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ezetimibe Ketone
  • (3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
  • (3R,4S,3'R)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[3'-(4-fluorophenyl)-3'-hydroxy-propyl]-azetidin-2-one
  • (3R,4S)-3-Azetidinepropanoic acid,1-(4-fluorophenyl)-2-oxo-4[4(phenylmethoxy)phenyl]-methyl ester
  • Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate

DownStream

Related Compounds

  • (R)-(+)-S-methyl tert-butylphenylphosphinothiolate
  • ((R)-6-benzylamino-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid tert-butyl ester
  • (R)-tert-butyl (1-(3-(4,4,5,5-ltetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)carbamate
  • (R)-1-(4-METHOXYPHENYL)ETHANOL
  • (R)-tert-butyl 6-hydroxy-1,4-oxazepane-4-carboxylate
  • [R-(R*,S*)]-(2-hydroxy-1-methyl-2-phenylethyl)dimethylammonium (1S)-2-oxobornane-10-sulphonate
  • 1-(Chloromethyl)-3-(3,4-dichlorophenyl)bicyclo[1.1.1]pentane
  • 1-(Chloromethyl)-3-[(2,6-dichlorophenyl)methyl]bicyclo[1.1.1]pentane
  • [3-(2,3-Dimethylphenyl)-1-bicyclo[1.1.1]pentanyl]methanamine
  • [3-(2-Fluoro-4-methylphenyl)-1-bicyclo[1.1.1]pentanyl]hydrazine
  • Ethyl 2-[(6S)-5-azaspiro[2.4]heptan-6-yl]acetate
  • Tert-butyl (3R)-4-amino-3-hydroxybutanoate
  • 2-Methyl-2-(1-phenylmethoxycarbonylpiperidin-4-yl)propanoic acid
  • 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(6-oxo-1H-pyrimidin-2-yl)propanoic acid
  • 6,6-Dimethyl-5,7-dihydropyrazolo[5,1-b][1,3]oxazine-3-sulfonyl fluoride
  • 6-Oxabicyclo[3.2.2]nonane-4-sulfonyl fluoride
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