Linezolid

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Names

[ CAS No. ]:
165800-03-3

[ Name ]:
Linezolid

[Synonym ]:
Linezolid
NDA 21-130 Zyvox
N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide
Linezlid
Zyvoxid
Acetamide, N-(((5S)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-
Zyvox
(S)-N-((3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
N-{[(5S)-3-(3-Fluor-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamid
N-({(5S)-3-[3-Fluor-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamid
Zyvoxam
Acetamide, N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
Zyvoxa
MFCD00937825
N-({(5S)-3-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphényl)-2-oxo-1,3-oxazolidin-5-yl]méthyl}acétamide
N-({(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
585.5±50.0 °C at 760 mmHg

[ Melting Point ]:
176-1780C

[ Molecular Formula ]:
C16H20FN3O4

[ Molecular Weight ]:
337.346

[ Flash Point ]:
307.9±30.1 °C

[ Exact Mass ]:
337.143799

[ PSA ]:
71.11000

[ LogP ]:
0.30

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H372

[ Precautionary Statements ]:
P314

[ Target Organs ]:
Bone

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
AC2720000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanoic anhydride
  • (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone
  • Deacetyl Linezolid
  • Acetyl chloride
  • Thioacetic acid
  • N-tert-octyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide
  • (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]amine p-TSA salt
  • (S)-3-(3-fluoro-4-(morpholino)phenyl)-5-(2-(hydroxyimino)propyl)oxazolidin-2-one
  • N-tert-butyl-N-(((S)-3-(3-fluoro-4-morpholinophenyl)-2-oxazolidin-5-yl)methyl)acetamide
  • 3-Fluoro-4-morpholinoaniline

DownStream

  • (S)-N-((3-(3-fluoro-4-Morpholinophenyl)-2-oxooxazolidin-5-yl)Methyl)ethanethioamide

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1.

Arch. Microbiol. 196(7) , 513-6, (2014)

Genome level analysis of bacterial strains provides information on genetic composition and resistance mechanisms to clinically relevant antibiotics. To date, whole genome characterization of linezolid...

Gingival pain: an unusual side effect of ziprasidone.

BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)

The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...

Once-weekly dalbavancin versus daily conventional therapy for skin infection.

N. Engl. J. Med. 370(23) , 2169-79, (2014)

Dalbavancin, a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long plasma half-life, allowing for once-weekly dosing. DISCOVER 1 and DISCOVER 2 were identicall...


More Articles

Related Compounds

  • Linezolid
  • Linezolid D3
  • (R)-Linezolid
  • Bis-Linezolid
  • (R)-Linezolid-d3
  • Linezolid N-Oxide
  • 1-[(1-Cyanocyclohexyl)carbamoyl]ethyl 2-{[(3,5-dimethyl-1,2-oxazol-4-YL)methyl]sulfanyl}benzoate
  • 2-(5-{[4-Benzylpiperidyl]ethyl}-1,3,4-oxadiazol-2-yl)thiophene
  • 1-[(2-Chloro-6-fluorophenyl)methyl]-4-[1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]piperazine
  • 4-(2-Fluorobenzoyl)-2-propylphenol
  • rac-(2S,6R)-2-Allyl-6-butyl-1,2,3,6-tetrahydropyridine
  • 1-Methyl-3-(1-(pyridin-4-yl)ethyl)thiourea
  • Methyl 4-(1-hydroxycyclopropyl)benzoate
  • Ethyl 6-benzyl-2-[(1-carbamoyl-1-cyanoprop-1-en-2-yl)amino]-4h,5h,6h,7h-thieno[2,3-c]pyridine-3-carboxylate
  • 3-(3,4-Difluorophenyl)-2-hydroxypropanoic acid
  • 2-(4-bromophenoxy)-N-(prop-2-yn-1-yl)acetamide
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