Linezolid

Modify Date: 2025-08-21 12:36:21

Linezolid structure	Common Name	Linezolid
	CAS Number	165800-03-3	Molecular Weight	337.346
	Density	1.3±0.1 g/cm3	Boiling Point	585.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₀FN₃O₄	Melting Point	176-1780C
	MSDS	Chinese USA	Flash Point	307.9±30.1 °C
	Symbol	GHS08	Signal Word	Danger

Use of Linezolid

Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.

Name	linezolid
Synonym	More Synonyms

Description	Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Clemett D, Markham A. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828. [2]. Chiappini E, Conti C, Galli L et al. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review. Clin Ther. 2010 Jan;32(1):66-88. [3]. Perry CM, Jarvis B. Linezolid: a review of its use in the management of serious gram-positive infections. Drugs. 2001;61(4):525-51. [4]. He MZ, Jiang YW, Cai C.Mechanisms and epidemiology of linezolid resistance in staphylococci.Zhonghua Jie He He Hu Xi Za Zhi. 2012 May;35(5):360-2. [5]. Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G.Linezolid is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA class II Transgenic Mice.Antimicrob Agents Chemother. 2012 Jul 30.

Description

Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.

Related Catalog

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

References

[1]. Clemett D, Markham A. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828.

[2]. Chiappini E, Conti C, Galli L et al. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review. Clin Ther. 2010 Jan;32(1):66-88.

[3]. Perry CM, Jarvis B. Linezolid: a review of its use in the management of serious gram-positive infections. Drugs. 2001;61(4):525-51.

[4]. He MZ, Jiang YW, Cai C.Mechanisms and epidemiology of linezolid resistance in staphylococci.Zhonghua Jie He He Hu Xi Za Zhi. 2012 May;35(5):360-2.

[5]. Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G.Linezolid is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA class II Transgenic Mice.Antimicrob Agents Chemother. 2012 Jul 30.

Density	1.3±0.1 g/cm3
Boiling Point	585.5±50.0 °C at 760 mmHg
Melting Point	176-1780C
Molecular Formula	C₁₆H₂₀FN₃O₄
Molecular Weight	337.346
Flash Point	307.9±30.1 °C
Exact Mass	337.143799
PSA	71.11000
LogP	0.30
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.554
Storage condition	Store at RT

Linezolid MSDS(Chinese)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H372
Precautionary Statements	P314
Target Organs	Bone
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	36
RIDADR	NONH for all modes of transport
RTECS	AC2720000
HS Code	2934999090

Precursor 10
CAS#:108-24-7 Ethanoic anhydride CAS#:168828-84-0 (R)-5-(Azidomet... CAS#:168828-90-8 Deacetyl Linezolid CAS#:75-36-5 Acetyl chloride
CAS#:507-09-5 Thioacetic acid CAS#:1215006-12-4 N-tert-octyl-N-... CAS#:1334229-25-2 (S)-N-[[3-(3-fl... CAS#:1088111-01-6 (S)-3-(3-fluoro...
CAS#:1215006-11-3 N-tert-butyl-N-... CAS#:93246-53-8 3-Fluoro-4-morp...
DownStream 1
CAS#:216868-57-4 (S)-N-((3-(3-fl...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1.

Arch. Microbiol. 196(7) , 513-6, (2014)

Genome level analysis of bacterial strains provides information on genetic composition and resistance mechanisms to clinically relevant antibiotics. To date, whole genome characterization of linezolid...

Gingival pain: an unusual side effect of ziprasidone.

BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)

The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...

Once-weekly dalbavancin versus daily conventional therapy for skin infection.

N. Engl. J. Med. 370(23) , 2169-79, (2014)

Dalbavancin, a lipoglycopeptide antibiotic agent that is active against gram-positive pathogens, has a long plasma half-life, allowing for once-weekly dosing. DISCOVER 1 and DISCOVER 2 were identicall...

Linezolid

NDA 21-130 Zyvox

N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Linezlid

Zyvoxid

Acetamide, N-(((5S)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-

Zyvox

(S)-N-((3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

N-{[(5S)-3-(3-Fluor-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamid

N-({(5S)-3-[3-Fluor-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamid

Zyvoxam

Acetamide, N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-

N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

Zyvoxa

MFCD00937825

N-({(5S)-3-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphényl)-2-oxo-1,3-oxazolidin-5-yl]méthyl}acétamide

N-({(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Linezolid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Linezolid
Price: ￥468.0/5g ￥148.0/1g
Purity: 99.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Linezolid (PNU-100766)
Price: $200.0/100mg $450.0/250mg $800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Linezolid (PNU-100766)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: linezolid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥117/1g

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Linezolid

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