2-Chloro-5-nitrobenzonitrile

Suppliers

Names

[ CAS No. ]:
16588-02-6

[ Name ]:
2-Chloro-5-nitrobenzonitrile

[Synonym ]:
2-Chlor-5-nitrobenzolcarbonitril
2-chlor-5-nitrobenzonitrile
2-Chloro-5-nitrobenzenenitrile
3-cyano-4-chloronitrobenzene
MFCD00007292
4-chloro-3-cyanonitrobenzene
1-CHLORO-2-CYANO-4-NITROBENZENE
2-chlor-5-nitrobenzonitril
2-chloro-5-nitro-benzonitrile
2-cyano-4-nitrochlorobenzene
EINECS 240-643-6
2-chloro-5-nitro-benzonitril
Benzonitrile, 2-chloro-5-nitro-
4-Chloro-3-cyano-1-nitrobenzene
5-Nitro-2-chlorobenzonitrile
2-chloro-3-cyano-5-nitrobenzene
BENZONITRILE,2-CHLORO-5-NITRO
2-Chloro-5-nitrobenzonitrile
2-Chloro-1-cyano-5-nitrobenzene

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
300.3±27.0 °C at 760 mmHg

[ Melting Point ]:
105-108ºC

[ Molecular Formula ]:
C7H3ClN2O2

[ Molecular Weight ]:
182.564

[ Flash Point ]:
135.4±23.7 °C

[ Exact Mass ]:
181.988312

[ PSA ]:
69.61000

[ LogP ]:
1.79

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.599

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DI3040000
CHEMICAL NAME :
Benzonitrile, 2-chloro-5-nitro-
CAS REGISTRY NUMBER :
16588-02-6
LAST UPDATED :
199209
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H3-Cl-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 19,225,1969

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
UN 3276

[ WGK Germany ]:
3

[ RTECS ]:
DI3040000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Nitrobenzonitrile
  • 2-Chloro-5-nitrobenzaldehyde
  • Sodium ethoxide
  • 2-Chlorobenzonitrile
  • Benzamide,2-chloro-5-nitro-
  • 2-Chloro-5-nitrobenzoic acid
  • Cyanogen chloride
  • (NZ)-N-[(2-chloro-5-nitro-phenyl)methylidene]hydroxylamine
  • Salicylamide
  • 2-chloro-5-nitro-benzaldehyde chlorimin

DownStream

  • 5-Amino-2-chlorobenzonitrile
  • 5-Nitro-2-(piperidin-1-yl)benzonitrile
  • 5-Nitro-1H-indazol-3-amine
  • 2-hydrazinyl-5-nitrobenzonitrile
  • 5-nitro-2-propoxybenzamide
  • Salicylic acid, 5-nitro-
  • hydrochloride of 3-dimethylaminopropionitrile
  • Acrylonitrile
  • 2-cyano-4-nitro-N,N-diethylaniline

Articles

Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes.

Xenobiotica 26(2) , 143-55, (1996)

1. Four different rat glutathione S-transferase (GST) isoenzymes, belonging to three different classes, were examined for their GSH conjugating capacity towards 11 2-substituted 1-chloro-4-nitrobenzen...

Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures.

J. Biomol. Screen. 12(3) , 396-405, (2007)

A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of rat cytosolic glutathione-S-transferases (c...


More Articles

Related Compounds

  • 2-chloro-5-nitrobenzonitrile
  • 2-Chloro-4-fluoro-5-nitrobenzonitrile
  • 2-chloro-3,4-dihydroxy-5-nitrobenzonitrile
  • 2-Chloro-5-(trifluoromethyl)benzonitrile
  • 2-chloro-5-(2-hydroxyphenyl)benzonitrile
  • 2-Chloro-5-ethyl-6-methyl-3-nitropyridine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 5-(1-Propyn-1-yl)-3-pyridinecarboxaldehyde
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 8-Amino-5-oxaspiro[3.5]nonane-2-carboxylic acid hydrochloride
  • tert-Butyl-DL-alanine