Metaxalone
Suppliers
Names
[ CAS No. ]:
1665-48-1
[ Name ]:
Metaxalone
[Synonym ]:
5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one
Metaxalone
5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone
2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-
Metaxolone
MFCD00867700
5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone
Skelaxin
EINECS 216-777-6
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
453.6±14.0 °C at 760 mmHg
[ Melting Point ]:
121-123ºC
[ Molecular Formula ]:
C12H15NO3
[ Molecular Weight ]:
221.252
[ Flash Point ]:
228.2±20.1 °C
[ Exact Mass ]:
221.105194
[ PSA ]:
47.56000
[ LogP ]:
2.42
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.525
[ Storage condition ]:
-20°C Freezer
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RQ3850000
- CHEMICAL NAME :
- 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
- CAS REGISTRY NUMBER :
- 1665-48-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C12-H15-N-O3
- MOLECULAR WEIGHT :
- 221.28
- WISWESSER LINE NOTATION :
- T5MVOTJ D1OR C1 E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 775 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 515 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1690 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,326,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 490 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Precautionary Statements ]:
P301 + P312 + P330
[ Hazard Codes ]:
F,T
[ Risk Phrases ]:
11-23/24/25-39/23/24/25
[ Safety Phrases ]:
7-16-36/37-45
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
RQ3850000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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