Metaxalone
Metaxalone structure
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Common Name | Metaxalone | ||
|---|---|---|---|---|
| CAS Number | 1665-48-1 | Molecular Weight | 221.252 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 453.6±14.0 °C at 760 mmHg | |
| Molecular Formula | C12H15NO3 | Melting Point | 121-123ºC | |
| MSDS | Chinese USA | Flash Point | 228.2±20.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of MetaxaloneMetaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. |
| Name | Metaxalone |
|---|---|
| Synonym | More Synonyms |
| Description | Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 453.6±14.0 °C at 760 mmHg |
| Melting Point | 121-123ºC |
| Molecular Formula | C12H15NO3 |
| Molecular Weight | 221.252 |
| Flash Point | 228.2±20.1 °C |
| Exact Mass | 221.105194 |
| PSA | 47.56000 |
| LogP | 2.42 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.525 |
| Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | NONH for all modes of transport |
| RTECS | RQ3850000 |
|
~97%
Metaxalone CAS#:1665-48-1 |
| Literature: Dabur Pharma Ltd. Patent: US2007/185177 A1, 2007 ; Location in patent: Page/Page column 8 ; |
|
~78%
Metaxalone CAS#:1665-48-1 |
| Literature: Yung Shin Pharma Ind. Co., Ltd. Patent: US6562980 B1, 2003 ; |
|
~92%
Metaxalone CAS#:1665-48-1 |
| Literature: BOEHRINGER INGELHEIM CHEMICALS, INC. Patent: WO2008/6096 A1, 2008 ; Location in patent: Page/Page column 2-4 ; |
|
~16%
Metaxalone CAS#:1665-48-1 |
| Literature: AUSPEX PHARMACEUTICALS, INC. Patent: US2009/270469 A1, 2009 ; Location in patent: Page/Page column 28 ; |
|
~%
Metaxalone CAS#:1665-48-1 |
| Literature: Journal of Medicinal Chemistry, , vol. 38, # 20 p. 3983 - 3994 |
![4-acetamidophenyl N-[3-(3,5-dimethylphenoxy)-2-hydroxypropyl]carbamate structure](https://image.chemsrc.com/caspic/374/153756-95-7.png)
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Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone.
Clin. Ther. 26(9) , 1355-67, (2004) Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support.The aim of this review was to discuss the etiology of low back pain an... |
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Development of a Stability-Indicating RP-UPLC Method for Rapid Determination of Metaxalone and its Degradation Products in Solid Oral Dosage Form.
Sci. Pharm. 80(2) , 353-66, (2012) A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination o... |
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Metaxalone (Skelaxin)-related death.
J. Anal. Toxicol. 28(6) , 537-41, (2004) The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatograp... |
| 5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one |
| 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one |
| Metaxalone |
| 5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one |
| 5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone |
| 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]- |
| Metaxolone |
| MFCD00867700 |
| 5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone |
| Skelaxin |
| EINECS 216-777-6 |