Avasimibe

Suppliers

Names

[ Name ]:
Avasimibe

[Synonym ]:
2,6-Diisopropylphenyl [(2,4,6-triisopropylphenyl)acetyl]sulfamate
Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
[2,6-di(propan-2-yl)phenyl] N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate
2,6-di(propan-2-yl)phenyl {[2,4,6-tri(propan-2-yl)phenyl]acetyl}sulfamate
Avasimibe
CI-1011

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Melting Point ]:
178-180° (Lee); mp 169.5-170.4° (Dozeman)

[ Molecular Formula ]:
C₂₉H₄₃NO₄S

[ Molecular Weight ]:
501.721

[ Exact Mass ]:
501.291290

[ PSA ]:
80.85000

[ LogP ]:
9.34

[ Appearance of Characters ]:
white to tan

[ Index of Refraction ]:
1.529

[ Storage condition ]:
room temp

[ Water Solubility ]:
DMSO: ≥40mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1482550

CHEMICAL NAME :: Benzeneacetamide, N-((2,6-bis(1-methylethyl)phenoxy)sulfonyl)-2,4,6-tri s(1-methylethyl)-

CAS REGISTRY NUMBER :: 166518-60-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C29-H43-N-O4-S

MOLECULAR WEIGHT :: 501.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 137 gm/kg/13W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 36(1, Pt 2),274,1997

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-[2,4,6-tri(propan-2-yl)phenyl]acetyl chloride
2,6-DIISOPROPYLPHENYL SULFAMATE
2,4,6-TRIISOPROPYLBENZOYL CHLORIDE
(2,4,6-TRIISOPROPYLPHENYL)METHANOL
2-[2,4,6-tri(propan-2-yl)phenyl]acetic acid
2,4,6-triisopropylbenzyl cyanide
2-(Bromomethyl)-1,3,5-triisopropylbenzene

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atherosclerosis.

Pathophysiol. Haemost. Thromb. 36(1) , 9-17, (2007)

The ability to modify the enzymatic processes involved in promoting atherosclerotic plaque disruption and to serially monitor atherosclerotic evolution could provide novel information in the managemen...

Coronary circulatory function in patients with the metabolic syndrome.

J. Nucl. Med. 52(9) , 1369-77, (2011)

The metabolic syndrome affects 25% of the U.S. population and greatly increases the risk of diabetes and coronary artery disease (CAD). We tested the hypothesis that the metabolic syndrome is associat...

Avasimibe and atorvastatin synergistically reduce cholesteryl ester content in THP-1 macrophages.

Eur. J. Pharmacol. 451(1) , 11-7, (2002)

Evidence suggests that the inhibition of both acyl-CoA:cholesterol acyltransferase and hydroxymethyl glutaryl-CoA reductase causes a synergistic direct antiatherosclerotic effect on the vessel wall. T...