Digoxigenin

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Names

[ Name ]:
Digoxigenin

[Synonym ]:
Lanadigenin
digitoxigenin
MFCD00871861
Lanadigigenin
3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3,12,14-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
Digoxigenine
Digoxigenin
EINECS 216-806-2

Chemical & Physical Properties

[ Density]:
1.297 g/cm3

[ Boiling Point ]:
589.4ºC at 760 mmHg

[ Melting Point ]:
222 °C(lit.)

[ Molecular Formula ]:
C₂₃H₃₄O₅

[ Molecular Weight ]:
390.51300

[ Flash Point ]:
203ºC

[ Exact Mass ]:
390.24100

[ PSA ]:
86.99000

[ LogP ]:
2.57510

[ Vapour Pressure ]:
2.4E-16mmHg at 25°C

[ Index of Refraction ]:
1.609

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH5390000

CHEMICAL NAME :: 5-beta-Card-20(22)-enolide, 3-beta,12-beta,14-trihydroxy-

CAS REGISTRY NUMBER :: 1672-46-4

BEILSTEIN REFERENCE NO. :: 0096479

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C23-H34-O5

MOLECULAR WEIGHT :: 390.57

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 F- DT5OV CUTJ IQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 244 ug/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year: 27,189,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 285 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,55,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3545 ug/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Cardiac - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,436,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 1620 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 8,18,1960 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H330

[ Precautionary Statements ]:
P260-P264-P280-P284-P302 + P350-P310

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
S36/37/39-S45

[ RIDADR ]:
UN 2811 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
FH5390000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

3-Acetyldigoxigenin
Deoxycholic acid
23,24-dinor-5β-chol-20(22)-ene-3α,12α-diol 3-monobenzoate
20-Methylen-5β-pregnan-3β,12α-diol-3-acetat
(R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-(1H-imidazol-1-yl)pentan-1-one
20-Methylen-5β-pregnan-3β,12α-diol-diacetat
(20R,S)-20,21-Epoxy-20-methyl-5β-pregnan-3β,12α-diol-diacetat
20-Methylen-5β-pregnan-3β,12α,21-triol-3-acetat
3β-Acetoxy-12α-hydroxy-20-methylen-5β-pregnan-21-al
Digitoxin

DownStream

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