N-Cbz-L-serine methyl ester

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Names

[ Name ]:
N-Cbz-L-serine methyl ester

[Synonym ]:
L-Serine, N-[(phenylmethoxy)carbonyl]-, methyl ester
Methyl N-[(benzyloxy)carbonyl]-L-serinate
N-Carbobenzyloxy-L-serine methyl ester
N-Carbobenzoxy-L-serine Methyl Ester
CBZ-L-Serine methyl ester
N-Cbz-L-serine Methyl Ester
N-Benzyloxycarbonyl-l-serine, methyl ester
MFCD00077039
Cbz-Ser-OMe
(S)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxypropanoate
methyl (2S)-3-hydroxy-2-(phenylmethoxycarbonylamino)propanoate
Z-Ser-OMe

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
442.6±45.0 °C at 760 mmHg

[ Melting Point ]:
41-43 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₅NO₅

[ Molecular Weight ]:
253.251

[ Flash Point ]:
221.5±28.7 °C

[ Exact Mass ]:
253.095016

[ PSA ]:
84.86000

[ LogP ]:
1.42

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.536

[ Storage condition ]:
-15°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

H-Ser-Ome·HCl
Benzyl chloroformate
N-Cbz-L-Serine
methyl iodide
Methanol
l-serine methyl ester
diazomethane
Dimethyl sulfate
benzyl triazolo[4,5-b]pyridine-1-carboxylate

DownStream

Cbz-beta-Amino-L-alanine
(S)-methyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride
(S)-BENZYL (3-HYDROXY-1-(METHYLAMINO)-1-OXOPROPAN-2-YL)CARBAMATE
Diphenyl phosphate
L-Serine,N-[(phenylmethoxy)carbonyl]-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-b-D-glucopyranosyl]-, methyl ester
o-tert-butyl-n-carbobenzoxy-l-serine methyl ester
N-Cbz-L-Serine
N-Benzyloxycarbonylserylleucinamide
Z-Ser-Gly-OH

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Stereoselective Synthesis of Differentially Protected Derivatives of the Higher Amino Sugars Destomic Acid and Lincosamine from Serine and Threonine.

J. Org. Chem. 61 , 581, (1996)

The aminoheptose destomic acid (3.5) and the aminooctose lincosamine (6.8) were synthesized in protected form by parallel sequences starting from the oxazolidine derivatives 2.4 and 5.1 of N-CBz serin...

Monache, G.D. et al.

Synthesis , 1155, (1995)

Demirci, F. et al.

Synthesis , 189, (1996)