Lificiguat

Suppliers

Names

[ Name ]:
Lificiguat

[Synonym ]:
2-{1-[(2R)-2-(2-Methoxyphenyl)-2-(tetrahydro-2H-pyran-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl}-2-methylpropanoic acid
Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-
ND-630
GS-0976
NDI-010976
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol
YC-1

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
522.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₆N₂O₂

[ Molecular Weight ]:
304.342

[ Flash Point ]:
269.6±30.1 °C

[ Exact Mass ]:
304.121185

[ PSA ]:
51.19000

[ LogP ]:
3.55

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.653

[ Storage condition ]:
-20℃

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-benzyl-3-(5-methoxycarbonyl-furan-2-yl)-1H-indazole
Methyl 2-furoate
1H-Indazole
1-Benzyl-3-Iodo-1H-Indazole
Methyl 5-benzoyl-2-furoate
5-methoxycarbonylfuryl phenyl ketone benzylhydrazone
3-Iodo-1H-indazole
Methyl 5-bromo-2-furoate
1-Benzyl-1,2-dihydro-3H-indazol-3-one

DownStream

Articles

VAV3 mediates resistance to breast cancer endocrine therapy.

Breast Cancer Res. 16(3) , R53, (2014)

Endocrine therapies targeting cell proliferation and survival mediated by estrogen receptor α (ERα) are among the most effective systemic treatments for ERα-positive breast cancer. However, most tumor...

Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition.

Am. J. Physiol. Cell Physiol. 309 , C239-50, (2015)

Protein kinase C can activate NADPH oxidase and induce glutathionylation of the β1-Na(+)-K(+) pump subunit, inhibiting activity of the catalytic α-subunit. To examine if signaling of nitric oxide-indu...

The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma.

Cancer Lett. 370 , 279-85, (2015)

Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with high mortality. Treatments, which can result in significant morbidity, have not substantially changed in three decades. The ...