Trost ligand

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Names

[ Name ]:
Trost ligand

[Synonym ]:
(1S,2S)-1,2-Bis(2-pyridinecarboxamido)cyclohexane
Trost ligand
N,N'-(1S,2S)-1,2-Cyclohexanediyldi(2-pyridinecarboxamide)
2-Pyridinecarboxamide, N,N'-(1S,2S)-1,2-cyclohexanediylbis-
(1S,2S)-N,N′-1,2-Cyclohexanediylbis(2-pyridinecarboxamide)
(S,S)-DACH-pyridyl Trost ligand
MFCD02684543

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
663.4±50.0 °C at 760 mmHg

[ Melting Point ]:
170ºC

[ Molecular Formula ]:
C₁₈H₂₀N₄O₂

[ Molecular Weight ]:
324.377

[ Flash Point ]:
355.0±30.1 °C

[ Exact Mass ]:
324.158630

[ PSA ]:
83.98000

[ LogP ]:
0.77

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.610

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Picolinic acid
(1S,2S)-(+)-1,2-Diaminocyclohexane
Ethyl 2-picolinate
carbon monoxide

DownStream

Articles

Asymmetric Transition Metal-Catalyzed Allylic Alkylations.

Chem. Rev. 96 , 395, (1996)

Asymmetric transition-metal-catalyzed allylic alkylations: applications in total synthesis.

Chem. Rev. 103 , 2921, (2003)

Trost, B.M. et al.

J. Am. Chem. Soc. 124 , 11616, (2004)

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