2-Amino-6-methoxybenzothiazole

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Names

[ Name ]:
2-Amino-6-methoxybenzothiazole

[Synonym ]:
2-Amino-6-methoxybenzothiazole
6-Methoxy-1,3-benzothiazol-2-amine
6-Methoxy-2-aminobenzothiazole
2-Benzothiazolamine, 6-methoxy-
EINECS 217-130-0
MFCD00005787

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
347.5±34.0 °C at 760 mmHg

[ Melting Point ]:
165-167 °C(lit.)

[ Molecular Formula ]:
C₈H₈N₂OS

[ Molecular Weight ]:
180.227

[ Flash Point ]:
163.9±25.7 °C

[ Exact Mass ]:
180.035736

[ PSA ]:
76.38000

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Stability ]:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
<0.1 g/100 mL at 21 ºC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL2100000

CHEMICAL NAME :: Benzothiazole, 2-amino-6-methoxy-

CAS REGISTRY NUMBER :: 1747-60-0

BEILSTEIN REFERENCE NO. :: 0131202

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-N2-O-S

MOLECULAR WEIGHT :: 180.24

WISWESSER LINE NOTATION :: T56 BN DSJ CZ GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 10 umol/L

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn,Xi

[ Risk Phrases ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ Safety Phrases ]:
S26

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
DL2100000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

6-methoxy-2-phenyl-1,3-benzothiazole
2-CHLORO-N-(6-METHOXY-BENZOTHIAZOL-2-YL)-ACETAMIDE
6-Methoxy-2(3H)-benzothiazolone
Thiocyanic acid, 6-methoxy-2-benzothiazolyl ester (8CI)
2-Amino-6-ethoxybenzothiazole
2-CYANO-6-HYDROXYBENZOTHIAZOLE
2-Cyano-6-methoxybenzothiazole
2-Hydrazino-6-methoxy-1,3-benzothiazole
2-Chloro-6-methoxybenzothiazole
2-BROMOBENZOTHIAZOL-6-OL

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and antimicrobial activity of new 4-thiazolidinone derivatives containing 2-amino-6-methoxybenzothiazole.

Saudi Pharm. J. 18(3) , 129-36, (2010)

A novel series of Schiff bases 5a-j and 4-thiazolidinones 6a-j have been prepared from the building blocks 2-chloro pyridine-3-carboxylic acid [1] and 2-amino-6-methoxy-benzothiazole [2]. All of the s...

Effect of Aroclor 1254 dose upon S9 activation of aromatic amine bacterial mutagens.

Mutat. Res. 77(4) , 361-6, (1980)

Structural, vibrational, electronic investigations and quantum chemical studies of 2-amino-4-methoxybenzothiazole.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 102 , 327-40, (2013)

Extensive vibrational investigations of 2-amino-4-methoxybenzothiazole have been carried out with FTIR and FT-Raman spectral techniques. The electronic structure of the molecule has been analysed by U...

2-amino-6-benzyl-3-methylsulfanyl-1,2,4-triazin-5-one
2-amino-6-phenyl-4-(trifluoromethyl)pyridine-3-carbonitrile
2-Amino-6-(trifluoromethyl)benzonitrile
2-amino-6-bromo-4-chlorophenol
2-Amino-6-bromothiazolo[5,4-b]pyridine
2-AMINO-6-MERCAPTOPYRIDINE-3,5-DICARBONITRILE