2-Methylquinazolin-4-ol

Suppliers

Names

[ CAS No. ]:
1769-24-0

[ Name ]:
2-Methylquinazolin-4-ol

[Synonym ]:
EINECS 217-189-2
MFCD00006887
2-methyl-4(3h)-quinazolinone

Chemical & Physical Properties

[ Density]:
1.26 g/cm3

[ Boiling Point ]:
305.4ºC at 760 mmHg

[ Melting Point ]:
231-233ºC(lit.)

[ Molecular Formula ]:
C₉H₈N₂O

[ Molecular Weight ]:
160.17300

[ Flash Point ]:
138.5ºC

[ Exact Mass ]:
160.06400

[ PSA ]:
45.75000

[ LogP ]:
1.23150

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA3677000

CHEMICAL NAME :: 4(3H)-Quinazolinone, 2-methyl-

CAS REGISTRY NUMBER :: 1769-24-0

LAST UPDATED :: 199609

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H8-N2-O

MOLECULAR WEIGHT :: 160.19

WISWESSER LINE NOTATION :: T66 BVM ENJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 859 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 592 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 7,626,1973

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26;S37/S39

[ WGK Germany ]:
3

[ RTECS ]:
VA3677000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-ACETAMIDOBENZAMIDE
Acetimidamide hydrochloride
2-Bromobenzoic acid
2-Iodobenzoic acid
2-Methyl-3,1-benzoxazin-4-one
Methyl 2-chlorobenzoate
Methyl 2-bromobenzoate
3-methyl-5-(o-nitrophenyl)-1,2,4-oxadiazole
Ethanoic anhydride

DownStream

4-Oxo-3,4-dihydroquinazoline-2-carbaldehyde
2,3-Dimethyl-3H-quinazolin-4-one
6-methyl-2,3-dihydro-[1,2,4]triazino[4,3-c]quinazolin-4-one
2-(bromomethyl)-1H-quinazolin-4-one
4(3H)-Quinazolinone,2-[2-(4-methoxyphenyl)ethenyl]-
2-methyl-3-amino-4-quinazolone
4-chloro-2-methylquinazoline
2-ethylquinazolin-4-ol
2-(CHLOROMETHYL)QUINAZOLIN-4(3H)-ONE
4-Chloro-2-(trichloromethyl)quinazoline

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%