2-Methylquinazolin-4-ol

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Names

[ CAS No. ]:
1769-24-0

[ Name ]:
2-Methylquinazolin-4-ol

[Synonym ]:
EINECS 217-189-2
MFCD00006887
2-methyl-4(3h)-quinazolinone

Chemical & Physical Properties

[ Density]:
1.26 g/cm3

[ Boiling Point ]:
305.4ºC at 760 mmHg

[ Melting Point ]:
231-233ºC(lit.)

[ Molecular Formula ]:
C9H8N2O

[ Molecular Weight ]:
160.17300

[ Flash Point ]:
138.5ºC

[ Exact Mass ]:
160.06400

[ PSA ]:
45.75000

[ LogP ]:
1.23150

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA3677000
CHEMICAL NAME :
4(3H)-Quinazolinone, 2-methyl-
CAS REGISTRY NUMBER :
1769-24-0
LAST UPDATED :
199609
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H8-N2-O
MOLECULAR WEIGHT :
160.19
WISWESSER LINE NOTATION :
T66 BVM ENJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
859 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
592 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - tremor Behavioral - muscle weakness
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 7,626,1973

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26;S37/S39

[ WGK Germany ]:
3

[ RTECS ]:
VA3677000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-ACETAMIDOBENZAMIDE
  • Acetimidamide hydrochloride
  • 2-Bromobenzoic acid
  • 2-Iodobenzoic acid
  • 2-Methyl-3,1-benzoxazin-4-one
  • Methyl 2-chlorobenzoate
  • Methyl 2-bromobenzoate
  • 3-methyl-5-(o-nitrophenyl)-1,2,4-oxadiazole
  • Ethanoic anhydride

DownStream

  • 4-Oxo-3,4-dihydroquinazoline-2-carbaldehyde
  • 2,3-Dimethyl-3H-quinazolin-4-one
  • 6-methyl-2,3-dihydro-[1,2,4]triazino[4,3-c]quinazolin-4-one
  • 2-(bromomethyl)-1H-quinazolin-4-one
  • 4(3H)-Quinazolinone,2-[2-(4-methoxyphenyl)ethenyl]-
  • 2-methyl-3-amino-4-quinazolone
  • 4-chloro-2-methylquinazoline
  • 2-ethylquinazolin-4-ol
  • 2-(CHLOROMETHYL)QUINAZOLIN-4(3H)-ONE
  • 4-Chloro-2-(trichloromethyl)quinazoline

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-Methylquinazolin-4-ol 3-oxide
  • 6-amino-2-methylquinazolin-4-ol
  • 8-Bromo-2-methylquinazolin-4-ol
  • 7-chloro-2-methylquinazolin-4-ol
  • 6-chloro-2-methylquinazolin-4-ol
  • 6-fluoro-2-methylquinazolin-4-ol
  • N-[(2-chloro-4-fluorophenyl)methyl]-4-(2-methylpropanamido)-3-(pyridin-2-yl)-1,2-thiazole-5-carboxamide
  • N-Cyclohexyl-4-cyclopropaneamido-3-(pyridin-2-YL)-1,2-thiazole-5-carboxamide
  • 1-(2,3-Dihydrobenzo[b][1,4]dioxine-5-carbonyl)piperidine-2-carboxylic acid
  • 2-(4-chlorophenyl)-8-(pyrrolidine-1-carbonyl)-2H-pyrazolo[4,3-c]quinolin-3(5H)-one
  • 2-[(6-Methoxypyridin-3-yl)amino]-1-(pyrrolidin-1-yl)propan-1-one
  • N-(1-acetylimidazol-4-yl)acetamide
  • N,1,3-trimethylpiperidin-4-amine
  • 2-chloro-N-[2-(dimethylamino)-2-(thiophen-2-yl)ethyl]pyridine-4-carboxamide
  • 2-chloro-N-{[4-(2-methylpropyl)morpholin-2-yl]methyl}pyridine-4-carboxamide
  • 3-[(2-Methyl-1,3-benzothiazol-6-yl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
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