6-hydroxy Warfarin

Names

[ CAS No. ]:
17834-02-5

[ Name ]:
6-hydroxy Warfarin

[Synonym ]:
6-Hydroxywarfarin
4,6-dihydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one

Chemical & Physical Properties

[ Density]:
1.384 g/cm3

[ Boiling Point ]:
540.2ºC at 760 mmHg

[ Melting Point ]:
119-120ºC

[ Molecular Formula ]:
C₁₉H₁₆O₅

[ Molecular Weight ]:
324.32700

[ Flash Point ]:
197.7ºC

[ Exact Mass ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
3.31520

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.659

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

ethyl 4,6-dihydroxy-2-oxochromene-3-carboxylate
Benzalacetone
Warfarin
Benzoic acid,2,5-bis(acetyloxy)-
Gentisic acid
(4-acetyloxy-3-carbonochloridoylphenyl) acetate
2,5-diacetoxybenzoic (ethyl carbonic) anhydride

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

J. Chromatogr. A. 1363 , 200-6, (2014)

Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase...

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.

Drug Metab. Lett. 6(3) , 157-64, (2012)

Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharm...