7-hydroxy Warfarin

Names

[ CAS No. ]:
17834-03-6

[ Name ]:
7-hydroxy Warfarin

[Synonym ]:
7-Hydroxywarfarin
4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one

Chemical & Physical Properties

[ Density]:
1.384g/cm3

[ Boiling Point ]:
540.2ºC at 760mmHg

[ Melting Point ]:
220ºC

[ Molecular Formula ]:
C₁₉H₁₆O₅

[ Molecular Weight ]:
324.33

[ Flash Point ]:
197.7ºC

[ Exact Mass ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
3.31520

[ Vapour Pressure ]:
1.68E-12mmHg at 25°C

[ Index of Refraction ]:
1.658

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.

Drug Metab. Dispos. 43 , 1408-16, (2015)

The common marmoset (Callithrix jacchus), a small New World monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. Four novel cDNAs, encoding cytochro...

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

J. Chromatogr. A. 1363 , 200-6, (2014)

Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase...

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

7-HYDROXYWARFARIN
7-Hydroxy Warfarin-d5
(R)-7-Hydroxy Warfarin
(7-BENZYL-7-AZABICYCLO[2.2.1]HEPTAN-1-YL)METHANAMINE
7-Hydroxymethyl-3-oxa-bicyclo[3.3.1]nonan-9-one
7-methylguanosine-5'-monophosphate
7-Ethyl-4-methyl-2,7-diazaspiro[4.5]decan-10-ol
7-(3,5-dimethylpiperidin-2-yl)-1H-indole
3-(piperidin-4-yloxy)-4,5,6,7-tetrahydro-1H-indazole
5-Bromo-7-methyl-2-(2-methylpropyl)-[1,2,4]triazolo[1,5-a]pyridine
5-Bromo-2-cyclobutyl-7-methyl-[1,2,4]triazolo[1,5-a]pyridine
4-Fluoro-2-(2-isocyanatoethyl)pyridine
I(2),I-Carotene, 1a(2),2a(2)-epoxy-1a(2),2a(2)-dihydro-, (2a(2)S)-
2,2-Difluoro-3-[methyl(thiolan-3-yl)amino]propanoic acid
Ethyl 2-chloro-4-methoxy-5-methylbenzoate
7-bromo-1-butyl-1H-1,3-benzodiazole

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