(3-Carboxypropyl)(triphenyl)phosphonium bromide

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Names

[ Name ]:
(3-Carboxypropyl)(triphenyl)phosphonium bromide

[Synonym ]:
(3-Carboxypropyl)triphenylphosphonium bromide
(3-Carboxypropyl)(triphenyl)phosphonium bromide
Ph3PCH2CH2CH2COOH bromide
Phosphonium, (3-carboxypropyl)triphenyl-, bromide (1:1)
(4-Hydroxy-4-oxobutyl)triphenylphosphonium bromide
MFCD00274196
3-Carboxypropyl triphenylphosphonium bromide

Chemical & Physical Properties

[ Melting Point ]:
244-247 °C(lit.)

[ Molecular Formula ]:
C₂₂H₂₂BrO₂P

[ Molecular Weight ]:
429.287

[ Exact Mass ]:
428.054077

[ PSA ]:
50.89000

[ LogP ]:
0.84930

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

4-Bromobutanoic acid
Triphenylphosphine
gamma-Butyrolactone
Triphenylphosphine hydrobromide (1:1)

DownStream

Phosphonium,(4-ethoxy-4-oxobutyl)triphenyl-, bromide (1:1)
2-CHLORO-6,7,8,9-TETRAHYDRO-BENZOCYCLOHEPTEN-5-ONE
2-Methoxy-6,7,8,9-tetrahydrobenzocyclohepten-5-one
2-Bromo-6,7,8,9-tetrahydrobenzocyclohepten-5-one
(4E)-4-[(1R,4S,5R,6S)-5-[(3S)-3-cyclohexyl-3-hydroxyprop-1-ynyl]-4-hydroxy-8-bicyclo[4.2.0]octanylidene]butanoic acid
(E)-4-((1S,2S,3R,6S)-2-((S)-3-cyclohexyl-3-hydroxyprop-1-yn-1-yl)-3-hydroxybicyclo[4.2.0]octan-7-ylidene)butanoic acid
5-(3-Methoxyphenyl)pentanoic acid
5H-Benzocyclohepten-5-one,6,7,8,9-tetrahydro-2-methoxy-3-nitro-
10-methoxy-11-nitro-bicyclo[5.4.0]undeca-8,10,12-trien-6-one
5-(4-METHYLPHENYL)VALERIC ACID

Articles

Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435/DOX cells.

Mol. Pharm. 11(8) , 2640-9, (2014)

In this study, doxorubicin (DOX) was conjugated to a lipophilic triphenylphosphonium (TPP) that is selectively taken up by the mitochondrial membrane of cells. This new derivative of DOX, i.e., TPP-DO...

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