pentachloroanisole
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Names
[ CAS No. ]:
1825-21-4
[ Name ]:
pentachloroanisole
[Synonym ]:
Methyl pentachlorophenyl ether
2,3,4,5,6-pentachloroanisole
pentachlorophenol anisole
Ether,methyl pentachlorophenyl
Pentachloromethoxybenzene
Methyl pentachlorophenate
Benzene,pentachloromethoxy
Anisole,2,3,4,5,6-pentachloro
Pentachlorophenyl methyl ether
Pentachloranisole
Methyl pentachlorophenyl ester
pentachloroanisol
Pentachloroanisole
Chemical & Physical Properties
[ Density]:
1.618g/cm3
[ Boiling Point ]:
321.5ºC at 760mmHg
[ Melting Point ]:
108-110℃
[ Molecular Formula ]:
C7H3Cl5O
[ Molecular Weight ]:
280.36300
[ Flash Point ]:
127.1ºC
[ Exact Mass ]:
277.86300
[ PSA ]:
9.23000
[ LogP ]:
4.96220
[ Vapour Pressure ]:
0.000557mmHg at 25°C
[ Index of Refraction ]:
1.577
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BZ8820000
- CHEMICAL NAME :
- Anisole, 2,3,4,5,6-pentachloro-
- CAS REGISTRY NUMBER :
- 1825-21-4
- BEILSTEIN REFERENCE NO. :
- 2052667
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C7-H3-Cl5-O
- MOLECULAR WEIGHT :
- 280.35
- WISWESSER LINE NOTATION :
- GR BG CG DG EG FO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 318 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 281 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg/16D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5200 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg/16D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2600 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10300 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20800 mg/kg/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - angiosarcoma Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 7420 mg/kg
- SEX/DURATION :
- female 23 week(s) pre-mating female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 724 mg/kg
- SEX/DURATION :
- female 23 week(s) pre-mating female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 75 mg/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,143,1987
Safety Information
[ Symbol ]:
GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H400
[ Precautionary Statements ]:
P273
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ RIDADR ]:
UN 2811
[ WGK Germany ]:
3.0
[ RTECS ]:
BZ8820000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2909309090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909309090
[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Environ. Mutagen. 9(2) , 143-60, (1987)
Nine substances were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay, by means of procedures based upon those described by Clive and Spector (Muta...
PLoS ONE 7(9) , e45887, (2012)
The occurrence of cytochrome P450 and P450-mediated pentachlorophenol oxidation in a white rot fungus Phanerochaete chrysosporium was demonstrated in this study. The carbon monoxide difference spectra...
J. Chromatogr. A. 1215(1-2) , 1-7, (2008)
Extraction of 2,4,6-tribromophenol (TBP), pentachlorophenol (PCP) and pentachloroanisole (PCA) from whole fat cow milk using headspace solid-phase microextraction (HS-SPME) with polyacrylate (PA) and ...