D-Mevalonolactone

Names

[ CAS No. ]:
19115-49-2

[ Name ]:
D-Mevalonolactone

[Synonym ]:
D-Mevalonic Acid Lactone
D-Mevalonolactone
Adeka mevalonolactone
mevalonic lactone
Mevalonic-D,L acid lactone
Prestwick_97
MFCD01074894

Chemical & Physical Properties

[ Density]:
1.189g/cm3

[ Boiling Point ]:
274.9ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₀O₃

[ Molecular Weight ]:
130.14200

[ Flash Point ]:
110ºC

[ Exact Mass ]:
130.06300

[ PSA ]:
46.53000

[ LogP ]:
0.07440

[ Vapour Pressure ]:
0.000662mmHg at 25°C

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.

Bioorg. Med. Chem. 17(23) , 7915-23, (2009)

A novel series of 2-cyclopropyl-4-thiophenyl quinoline-based mevalonolactones were synthesized from the substituted anilines by several reactions. Among them, (4R,6S)-6-[(E)-2-(2-cyclopropyl-6-fluoro-...

Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.

J. Lipid Res. 48(5) , 1212-20, (2007)

We have developed a new sensitive and specific nonradioisotope assay method to measure the activity of HMG-CoA reductase, the rate-controlling enzyme in the cholesterol biosynthetic pathway. This meth...

Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS.

Anal. Biochem. 329(1) , 28-34, (2004)

We present an integrated consolidation of previously reported methods for screening hydroxymethylglutaryl-coenzyme A reductase (HMGR) inhibitors in 96-well microtiter plates with rapid workup using es...