(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

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Names

[ CAS No. ]:
19685-10-0

[ Name ]:
(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

[Synonym ]:
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-9-methoxy-, (4S)-
(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
10-methoxycamptothecin
10-MethoxycaMptothecine

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
773.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H18N2O5

[ Molecular Weight ]:
378.378

[ Flash Point ]:
421.4±32.9 °C

[ Exact Mass ]:
378.121582

[ PSA ]:
90.65000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.723

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (4S)-4-ethyl-3,4-dihydroxy-9-methoxy-3,4-dihydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14(12H)-one
  • 1-isocyano-4-methoxybenzene
  • (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-propargyl-1H-pyrano[3,4-c]-8-pyridone
  • diazomethane
  • (S)-10-Hydroxycamptothecin
  • methyl iodide
  • Campathecin
  • Camptothecin N-oxide

DownStream

  • (S)-10-Hydroxycamptothecin
  • Topotecan hydrochloride
  • (4S)-4α-Ethyl-4-hydroxy-7-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Related Compounds

  • (2R)-2-{benzyl[(benzyloxy)carbonyl]amino}propanoic acid
  • 2-(2-{[(Benzyloxy)carbonyl]amino}-1,3-thiazol-4-yl)-2-methylpropanoic acid
  • rac-ethyl (1R,5R)-2-azabicyclo[3.2.0]heptane-1-carboxylate
  • Tert-butyl 1,1-dioxo-1lambda6,4-thiazepane-6-carboxylate
  • 5-{[(Tert-butoxy)carbonyl]amino}-3-methylpyridine-2-carboxylic acid
  • 3-{[(Benzyloxy)carbonyl](methyl)amino}-4,4-difluorobutanoic acid
  • methyl 2-methyl-hexahydro-2H-furo[3,2-b]pyrrole-5-carboxylate
  • Methyl 7-cyano-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
  • 2-{1-[(Benzyloxy)carbonyl]-5,5-dimethylpiperidin-2-yl}acetic acid
  • 5-{[(Benzyloxy)carbonyl]amino}bicyclo[2.2.2]octane-2-carboxylic acid
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