(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

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Names

[ CAS No. ]:
19685-10-0

[ Name ]:
(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

[Synonym ]:
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-9-methoxy-, (4S)-
(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
10-methoxycamptothecin
10-MethoxycaMptothecine

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
773.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H18N2O5

[ Molecular Weight ]:
378.378

[ Flash Point ]:
421.4±32.9 °C

[ Exact Mass ]:
378.121582

[ PSA ]:
90.65000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.723

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (4S)-4-ethyl-3,4-dihydroxy-9-methoxy-3,4-dihydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14(12H)-one
  • 1-isocyano-4-methoxybenzene
  • (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-propargyl-1H-pyrano[3,4-c]-8-pyridone
  • diazomethane
  • (S)-10-Hydroxycamptothecin
  • methyl iodide
  • Campathecin
  • Camptothecin N-oxide

DownStream

  • (S)-10-Hydroxycamptothecin
  • Topotecan hydrochloride
  • (4S)-4α-Ethyl-4-hydroxy-7-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Related Compounds

  • 4-(2-Aminopropan-2-yl)-3-fluorobenzenesulfonamide
  • Bis(propan-2-yl) [(2-aminoethoxy)methyl]phosphonate
  • tert-butyl 2-(2-aminoethyl)-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate
  • 2-[2-(Methylamino)pyrimidin-5-yl]ethan-1-ol
  • tert-Butyl (1-amino-1-(naphthalen-2-yl)propan-2-yl)carbamate
  • 4,4-Difluoro-3-(morpholin-4-yl)butan-1-amine
  • Methyl 4-(aminomethyl)-1-benzylpiperidine-4-carboxylate
  • Chloromethyl 3-((tert-butoxycarbonyl)amino)butanoate
  • tert-butyl N-(1-amino-1-cyclohexyl-3-methylbutan-2-yl)carbamate
  • 1-(2,2-Difluoroethyl)-5-methyl-1H-pyrazol-4-amine
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