(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

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Names

[ CAS No. ]:
19685-10-0

[ Name ]:
(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

[Synonym ]:
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-9-methoxy-, (4S)-
(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
10-methoxycamptothecin
10-MethoxycaMptothecine

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
773.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H18N2O5

[ Molecular Weight ]:
378.378

[ Flash Point ]:
421.4±32.9 °C

[ Exact Mass ]:
378.121582

[ PSA ]:
90.65000

[ LogP ]:
1.69

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.723

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (4S)-4-ethyl-3,4-dihydroxy-9-methoxy-3,4-dihydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14(12H)-one
  • 1-isocyano-4-methoxybenzene
  • (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-propargyl-1H-pyrano[3,4-c]-8-pyridone
  • diazomethane
  • (S)-10-Hydroxycamptothecin
  • methyl iodide
  • Campathecin
  • Camptothecin N-oxide

DownStream

  • (S)-10-Hydroxycamptothecin
  • Topotecan hydrochloride
  • (4S)-4α-Ethyl-4-hydroxy-7-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Related Compounds

  • 1-Cyclobutanecarbonylpyrazolidin-3-one
  • 1-(2-Methylpentanoyl)pyrazolidin-3-one
  • 1-(1-Methylcyclopropanecarbonyl)pyrazolidin-3-one
  • 2-Bromo-6-(prop-1-en-2-yl)-[1,2,4]triazolo[1,5-a]pyridine
  • [(2,3-Difluoropyridin-4-yl)methyl](ethyl)amine
  • 2-Methyl-2,3-dihydro-1-benzofuran-5-sulfonyl fluoride
  • Methyl 2-chloro-5-(fluorosulfonyl)benzoate
  • 3-bromo-1-methyl-5-(trichloroacetyl)-1H-pyrrole-2-sulfonyl fluoride
  • 5-(Fluorosulfonyl)-2,3-dimethoxybenzoic acid
  • 4-Methyl-2-oxo-2,3-dihydro-1,3-thiazole-5-sulfonyl fluoride
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