(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Modify Date: 2024-01-03 11:23:56

(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione structure	Common Name	(4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
	CAS Number	19685-10-0	Molecular Weight	378.378
	Density	1.5±0.1 g/cm3	Boiling Point	773.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₈N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	421.4±32.9 °C

Use of (4S)-4-Ethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines[1].

Name	9-methoxycamptothecine
Synonym	More Synonyms

Description	10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Zheng J, et al. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:81-7.

Density	1.5±0.1 g/cm3
Boiling Point	773.1±60.0 °C at 760 mmHg
Molecular Formula	C₂₁H₁₈N₂O₅
Molecular Weight	378.378
Flash Point	421.4±32.9 °C
Exact Mass	378.121582
PSA	90.65000
LogP	1.69
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.723
Storage condition	2-8C

Precursor 8
CAS#:1088402-95-2 (4S)-4-ethyl-3,... CAS#:10349-38-9 1-isocyano-4-me... CAS#:174092-80-9 (S)-4-Ethyl-4-h... CAS#:186581-53-3 diazomethane
CAS#:19685-09-7 (S)-10-Hydroxyc... CAS#:74-88-4 methyl iodide CAS#:7689-03-4 Campathecin CAS#:86639-48-7 Camptothecin N-oxide
DownStream 3
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