Ro 61-8048

Names

[ CAS No. ]:
199666-03-0

[ Name ]:
Ro 61-8048

[Synonym ]:
Ro 61-8048
3,4-Dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
627.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₅N₃O₆S₂

[ Molecular Weight ]:
421.448

[ Flash Point ]:
333.3±34.3 °C

[ Exact Mass ]:
421.040222

[ PSA ]:
159.96000

[ LogP ]:
3.38

[ Appearance of Characters ]:
light yellow solid

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.641

[ Storage condition ]:
-20℃

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.

Eur. J. Pharmacol. 478(1) , 47-52, (2003)

The effects of the novel kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide (Ro 61-8048) on severity of dystonia were examined in dt(sz) mutant hamste...

Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.

Eur. J. Pharmacol. 586(1-3) , 156-9, (2008)

Striatal dysfunctions seem to play a key role in the pathophysiology of dystonia in the dt(sz) mutant hamster, a model of paroxysmal non-kinesigenic dyskinesia, in which stress precipitates dystonic e...

The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal.

PLoS ONE 7(6) , e38349, (2012)

In the midgut of the mosquito Aedes aegypti, a vector of dengue and yellow fever, an intense release of heme and iron takes place during the digestion of a blood meal. Here, we demonstrated via chroma...