Ro 61-8048
Ro 61-8048 structure
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Common Name | Ro 61-8048 | ||
|---|---|---|---|---|
| CAS Number | 199666-03-0 | Molecular Weight | 421.448 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 627.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C17H15N3O6S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 333.3±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.
Eur. J. Pharmacol. 478(1) , 47-52, (2003) The effects of the novel kynurenine 3-hydroxylase inhibitor 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide (Ro 61-8048) on severity of dystonia were examined in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress... |
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Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.
Eur. J. Pharmacol. 586(1-3) , 156-9, (2008) Striatal dysfunctions seem to play a key role in the pathophysiology of dystonia in the dt(sz) mutant hamster, a model of paroxysmal non-kinesigenic dyskinesia, in which stress precipitates dystonic episodes. Previous examinations have shown changes in kynure... |
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The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal.
PLoS ONE 7(6) , e38349, (2012) In the midgut of the mosquito Aedes aegypti, a vector of dengue and yellow fever, an intense release of heme and iron takes place during the digestion of a blood meal. Here, we demonstrated via chromatography, light absorption and mass spectrometry that xanth... |
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Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
Brain 132 , 1259-67, (2009) Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense, and is a major cause of systemic and neurological disability throughout sub-Saharan Africa. Following ear... |