N-t-BOC-4,4-Difluoro-L-Proline

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Names

[ CAS No. ]:
203866-15-3

[ Name ]:
N-t-BOC-4,4-Difluoro-L-Proline

[Synonym ]:
4,4-Difluoro-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
1-(tert-Butoxycarbonyl)-4,4-difluoro-L-proline
N-(tert-Butoxycarbonyl)-4,4-difluoro-L-proline
BOC-L-4,4-DIFLUOROPROLINE
MFCD03094917
(2s)-1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid
(S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic Acid
(S)-1-(tert-Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid
N-t-BOC-4,4-Difluoro-L-Proline
N-Boc-4,4-difluoro-L-proline
1,2-Pyrrolidinedicarboxylic acid, 4,4-difluoro-, 1-(1,1-dimethylethyl) ester, (2S)-
(S)-1-Boc-4,4-difluoro-2-pyrrolidinecarboxylic Acid
1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-(2S)-carboxylic acid
N-Boc-(2S)-4,4-difluoroproline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
340.4±42.0 °C at 760 mmHg

[ Melting Point ]:
120-124ºC

[ Molecular Formula ]:
C10H15F2NO4

[ Molecular Weight ]:
251.227

[ Flash Point ]:
159.7±27.9 °C

[ Exact Mass ]:
251.096909

[ PSA ]:
66.84000

[ LogP ]:
0.66

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.475

[ Storage condition ]:
Store at 0-5°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-t-BOC-4,4-Difluoro-L-proline methyl ester
  • Boc-4-oxo-Pro-OMe
  • Boc-Hyp-OMe
  • Di-tert-butyl dicarbonate
  • H-Hyp-OMe hydrochloride

DownStream

  • (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)-pyrrolidine-1-carboxylate
  • N-t-BOC-4,4-Difluoro-L-prolinamide
  • (S)-4,4-Difluoropyrrolidine-2-carboxylic acid

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-t-BOC-4,4-Difluoro-L-proline methyl ester
  • N-t-BOC-4,4-Difluoro-L-prolinamide
  • N-t-BOC-4-Methylene-L-proline
  • N-T-BOC-L-PROLINE-N-HYDROXYSUCCINIMIDE ESTER
  • ditert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate
  • N-Boc-4-oxo-L-proline
  • 1-[7-Methoxy-3-(trifluoromethyl)quinolin-6-yl]pyrrolidin-2-one
  • Tert-butyl 4-(3-amino-4-hydroxy-3-methylbutyl)piperazine-1-carboxylate
  • 5,7-Dimethyl-3-(trifluoromethyl)quinoline
  • N-{1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl}-2-oxabicyclo[2.2.2]octane-1-carboxamide hydrochloride
  • 2-methyl-8-(trifluoromethyl)-2H,3H,4H-[1,4]oxazino[2,3-g]quinolin-3-one
  • [2,2-dimethyl-3-(1-methyl-4-nitro-1H-pyrazol-5-yl)cyclopropyl]methanamine
  • methyl 2-hydroxy-3-(4,5,6,7-tetrahydro-1H-indol-2-yl)propanoate
  • methyl 4-amino-3-(3,4-dihydro-2H-pyran-5-yl)butanoate
  • (3R)-3-hydroxy-3-(2,4,6-trihydroxyphenyl)propanoic acid
  • 1-[1-(3,4-dihydro-1H-2-benzopyran-6-yl)cyclopropyl]ethan-1-one
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