N-t-BOC-4,4-Difluoro-L-Proline

Modify Date: 2025-08-20 10:54:38

N-t-BOC-4,4-Difluoro-L-Proline Structure
N-t-BOC-4,4-Difluoro-L-Proline structure
 Common Name N-t-BOC-4,4-Difluoro-L-Proline
CAS Number 203866-15-3 Molecular Weight 251.227
Density 1.3±0.1 g/cm3 Boiling Point 340.4±42.0 °C at 760 mmHg
Molecular Formula C10H15F2NO4 Melting Point 120-124ºC
MSDS Chinese USA Flash Point 159.7±27.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Names

Name (2S)-4,4-difluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 340.4±42.0 °C at 760 mmHg
Melting Point 120-124ºC
Molecular Formula C10H15F2NO4
Molecular Weight 251.227
Flash Point 159.7±27.9 °C
Exact Mass 251.096909
PSA 66.84000
LogP 0.66
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.475
Storage condition Store at 0-5°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37
RIDADR NONH for all modes of transport
HS Code 2933990090

 Synthetic Route

N-t-BOC-4,4-Difluoro-L-proline methyl ester structure

N-t-BOC-4,4-Dif...

CAS#:203866-17-5

~97%

N-t-BOC-4,4-Difluoro-L-Proline Structure

N-t-BOC-4,4-Dif...

CAS#:203866-15-3

Literature: ALMIRALL, S.A.; BERNAL ANCHUELA, Francisco Javier; CARRASCAL RIERA, Marta; CATURLA JAVALOYES, Juan Francisco; GRACIA FERRER, Jordi; MATASSA, Victor Giulio; TERRICABRAS BELART, Emma; TALTAVULL MOLL, Joan; ERRA SOLA, Montserrat Patent: WO2012/146666 A1, 2012 ; Location in patent: Page/Page column 138-139 ; WO 2012/146666 A1
Boc-4-oxo-Pro-OMe structure

Boc-4-oxo-Pro-OMe

CAS#:102195-80-2

~%

N-t-BOC-4,4-Difluoro-L-Proline Structure

N-t-BOC-4,4-Dif...

CAS#:203866-15-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 8 p. 2725 - 2746
Boc-Hyp-OMe structure

Boc-Hyp-OMe

CAS#:74844-91-0

~%

N-t-BOC-4,4-Difluoro-L-Proline Structure

N-t-BOC-4,4-Dif...

CAS#:203866-15-3

Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 8 p. 2725 - 2746
Di-tert-butyl dicarbonate structure

Di-tert-butyl d...

CAS#:24424-99-5

~%

N-t-BOC-4,4-Difluoro-L-Proline Structure

N-t-BOC-4,4-Dif...

CAS#:203866-15-3

Literature: Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
H-Hyp-OMe hydrochloride structure

H-Hyp-OMe hydro...

CAS#:40216-83-9

~%

N-t-BOC-4,4-Difluoro-L-Proline Structure

N-t-BOC-4,4-Dif...

CAS#:203866-15-3

Literature: Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4,4-Difluoro-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
1-(tert-Butoxycarbonyl)-4,4-difluoro-L-proline
N-(tert-Butoxycarbonyl)-4,4-difluoro-L-proline
BOC-L-4,4-DIFLUOROPROLINE
MFCD03094917
(2s)-1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid
(S)-1-(tert-Butoxycarbonyl)-4,4-difluoro-2-pyrrolidinecarboxylic Acid
(S)-1-(tert-Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid
N-t-BOC-4,4-Difluoro-L-Proline
N-Boc-4,4-difluoro-L-proline
1,2-Pyrrolidinedicarboxylic acid, 4,4-difluoro-, 1-(1,1-dimethylethyl) ester, (2S)-
(S)-1-Boc-4,4-difluoro-2-pyrrolidinecarboxylic Acid
1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-(2S)-carboxylic acid
N-Boc-(2S)-4,4-difluoroproline
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Chemsrc provides N-t-BOC-4,4-Difluoro-L-Proline(CAS#:203866-15-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of N-t-BOC-4,4-Difluoro-L-Proline are included as well.>> amp version: N-t-BOC-4,4-Difluoro-L-Proline

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