JS-K

Names

[ CAS No. ]:
205432-12-8

[ Name ]:
JS-K

[Synonym ]:
HMS3261L12
O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate
JS-K

Chemical & Physical Properties

[ Density]:
1.606g/cm3

[ Boiling Point ]:
546.692ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₆N₆O₈

[ Molecular Weight ]:
384.30200

[ Flash Point ]:
284.429ºC

[ Exact Mass ]:
384.10300

[ PSA ]:
174.76000

[ LogP ]:
2.89380

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.656

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TL1364200

Precursor & DownStream

Precursor

DownStream

Articles

N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia.

Macromol. Biosci. 16 , 121-8, (2016)

There is a need for new treatment strategies of acute myeloid leukemia (AML). In this study, four different drugs, including cytarabine, daunorubicin, GDC-0980, and JS-K, were investigated in vitro fo...

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.

Redox Biol. 1 , 115-24, (2013)

JS-K is a nitric oxide (NO)-releasing prodrug of the O (2)-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in...

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells.

BMC Cancer 12 , 130, (2012)

Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In conseq...

Shellsol K
Bay K-8644
Cathepsin K inhibitor 3
Shinjulactone K
Benzo[k]fluoranthene-d12
Mumeose K
2-chloro-N-(3-(6-(pyrrolidin-1-yl)pyridazin-3-yl)phenyl)benzenesulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-2,4-dimethylbenzene-1-sulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-2,4,5-trimethylbenzene-1-sulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-4-ethylbenzene-1-sulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-4-bromobenzene-1-sulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-5-chlorothiophene-2-sulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-3-chlorobenzene-1-sulfonamide
N-{3-[6-(azepan-1-yl)pyridazin-3-yl]phenyl}-2-chlorobenzene-1-sulfonamide
4-acetyl-N-{3-[6-(4-methylpiperidin-1-yl)pyridazin-3-yl]phenyl}benzene-1-sulfonamide

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