JS-K
JS-K structure
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Common Name | JS-K | ||
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| CAS Number | 205432-12-8 | Molecular Weight | 384.30200 | |
| Density | 1.606g/cm3 | Boiling Point | 546.692ºC at 760 mmHg | |
| Molecular Formula | C13H16N6O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 284.429ºC | |
Use of JS-KJS-K is a NO donor that reacts with glutathione to generate NO at physiological pH[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells[2]. |
| Name | (Z)-(2,4-dinitrophenoxy)imino-(4-ethoxycarbonylpiperazin-1-yl)-oxidoazanium |
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| Synonym | More Synonyms |
| Description | JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells[2]. |
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| Related Catalog | |
| References |
| Density | 1.606g/cm3 |
|---|---|
| Boiling Point | 546.692ºC at 760 mmHg |
| Molecular Formula | C13H16N6O8 |
| Molecular Weight | 384.30200 |
| Flash Point | 284.429ºC |
| Exact Mass | 384.10300 |
| PSA | 174.76000 |
| LogP | 2.89380 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.656 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TL1364200 |
| Precursor 0 | |
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| DownStream 1 | |
CAS#:120-43-4|
N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia.
Macromol. Biosci. 16 , 121-8, (2016) There is a need for new treatment strategies of acute myeloid leukemia (AML). In this study, four different drugs, including cytarabine, daunorubicin, GDC-0980, and JS-K, were investigated in vitro fo... |
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Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.
Redox Biol. 1 , 115-24, (2013) JS-K is a nitric oxide (NO)-releasing prodrug of the O (2)-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in... |
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JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells.
BMC Cancer 12 , 130, (2012) Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In conseq... |
| HMS3261L12 |
| O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate |
| JS-K |