Benzylhydrazine dihydrochloride

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Names

[ CAS No. ]:
20570-96-1

[ Name ]:
Benzylhydrazine dihydrochloride

[Synonym ]:
EINECS 243-887-1
BENZYL HYDRAZINE di HCl
Benzylhydrazine dihydrochloride
1-benzylhydrazine dihydrochloride
Hydrazine,benzyl-,dihydrochloride
Hydrazine, (phenylmethyl)-, hydrochloride (1:2)
BnNHNH2*2HCl
N-benzylhydrazine dihydrochloride
(phenylmethyl)hydrazine dihydrochloride
benzylhydrazine*2HCl
MFCD00012921
Benzyl-hydrazine dihydrochloride
benzylhydrazine dihydrogen chloride

Chemical & Physical Properties

[ Density]:
1.033g/cm3

[ Boiling Point ]:
265.4ºC at 760 mmHg

[ Melting Point ]:
143-145 °C (dec.)(lit.)

[ Molecular Formula ]:
C7H12Cl2N2

[ Molecular Weight ]:
195.090

[ Flash Point ]:
132ºC

[ Exact Mass ]:
194.037750

[ PSA ]:
38.05000

[ LogP ]:
3.34510

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU8540000
CHEMICAL NAME :
Hydrazine, benzyl-, dihydrochloride
CAS REGISTRY NUMBER :
20570-96-1
LAST UPDATED :
198910
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C7-H10-N2.2Cl-H
MOLECULAR WEIGHT :
195.11
WISWESSER LINE NOTATION :
ZM1R &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg/29W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
10 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
MU8540000

[ Hazard Class ]:
6.1

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • tert-butyl 1-benzyl-2-(propan-2-ylidene)hydrazine-1-carboxylate

DownStream

  • Isocarboxazid
  • 1-Benzyl-3-(trifluoromethyl)-1H-pyrazol-5-ol
  • 5-Amino-1-benzyl-1H-pyrazole-4-carbonitrile
  • 3-Amino-1-benzyl-1H-pyrazole-4-carbonitrile
  • 1-benzyl-5-methylpyrazolidin-3-one
  • 2-benzyl-5-methylpyrazolidin-3-one
  • Ethyl 5-amino-1-benzyl-1H-pyrazole-4-carboxylate
  • Benzylhydrazine
  • 1-Benzyl-1H-pyrazole-4-carbonitrile

Preparation


Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Determination of hydrazine in pharmaceuticals IV: Hydrazine and benzylhydrazine in isocarboxazid.

J. Pharm. Sci. 74(1) , 105-7, (1985)

A GC procedure for the simultaneous determination of hydrazine and benzylhydrazine in isocarboxazid raw material and tablet formulations has been developed. The method is based on the reaction of benz...

Benzylhydrazine as a pseudo-substrate of bovine serum amine oxidase.

Biochem. J. 260(1) , 19-25, (1989)

Bovine serum amine oxidase is inhibited by benzylhydrazine (BHy), but recovers full activity after a few hours incubation [Hucko-Haas & Reed (1970) Biochem. Biophys. Res. Commun. 38, 396-400]. The fir...

Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay.

Bioorg. Med. Chem. 12(13) , 3649-55, (2004)

A series of indole-2-carboxylic acid benzylidene-hydrazides has been identified as a new class of potent apoptosis inducers through a novel cell-based caspase HTS assay. The screening hit, 5-chloro-3-...


More Articles

Related Compounds

  • 2-Bromobenzylhydrazine dihydrochloride
  • 3-METHOXYBENZYLHYDRAZINE DIHYDROCHLORIDE
  • 3-Methoxybenzylhydrazine dihydrochloride
  • 2-Methoxybenzylhydrazine dihydrochloride
  • 3-TrifluoroMethoxybenzylhydrazine dihydrochloride
  • ethyl (2R)-2-[2-[[(2R)-1-ethoxy-1-oxo-3-sulfanylpropan-2-yl]amino]ethylamino]-3-sulfanylpropanoate,dihydrochloride
  • N-[(1S)-1-(4-Ethylphenyl)ethyl]-1-prop-2-enoylpiperidine-4-carboxamide
  • N-[3-Oxo-3-(2-propylmorpholin-4-yl)propyl]prop-2-enamide
  • 4-Chloro-3,5-dimethylphenyl 2-nitrobenzene-1-sulfonate
  • Tert-butyl 3-bromospiro[indene-1,4'-piperidine]-1'-carboxylate
  • N-(3-Hydroxy-1-phenylpropyl)-1-prop-2-enoylpiperidine-4-carboxamide
  • N-(3-Hydroxy-1-thiophen-2-ylpropyl)-1-prop-2-enoylpiperidine-4-carboxamide
  • N-[[4-[4-(Methanesulfonamido)piperidine-1-carbonyl]phenyl]methyl]prop-2-enamide
  • N-(4-ethyloxan-4-yl)-1-(prop-2-enoyl)piperidine-4-carboxamide
  • N-(4-Ethyloxan-4-yl)-3-(prop-2-enoylamino)propanamide
  • N-{4-[(ethylsulfanyl)methyl]pyridin-2-yl}-1-(prop-2-enoyl)piperidine-4-carboxamide