W-84 dibromide

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Names

[ CAS No. ]:
21093-51-6

[ Name ]:
W-84 dibromide

[Synonym ]:
Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Hdmppa
W-84 dibromide
W-84

Chemical & Physical Properties

[ Molecular Formula ]:
C32H44Br2N4O4

[ Molecular Weight ]:
708.52400

[ Exact Mass ]:
706.17300

[ PSA ]:
74.76000

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,6-Dibromohexane
  • 2-[3-(dimethylamino)propyl]isoindole-1,3-dione
  • Phthalic anhydride
  • 3-Dimethylaminopropylamine

DownStream

Articles

Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria.

Eur. J. Pharmacol. 272 , 103-106, (1995)

Alcuronium is known to stabilize allosterically the binding of the muscarinic antagonist N-methylscopolamine to muscarinic M2 receptors and thus to elevate the equilibrium binding of N-methylscopolami...

Allosteric modulation of G protein-coupled receptors: perspectives and recent developments.

Drug Discov. Today 9 , 752-758, (2004)

Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or...

A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts.

J. Pharm. Pharmacol. 46(2) , 108-12, (1994)

W84 (N,N,N',N'-tetramethyl-N,N'-bis-(3-phthalimidopropyl)-N,N'-hexane- 1,6- diyl-bis-ammonium dibromide) is a potent stabilizer of antagonist binding to muscarinic receptors; however, W84 hydrolyses i...


More Articles

Related Compounds

  • W-84 dibromide
  • w-Conotoxin SVIB
  • W(CO)4(piperidine)2
  • W 54011
  • W 10294A
  • W(O)Cl2(PMePh2)2(ethylene)
  • N-(3-{[hydroxy(methyl)amino]methyl}phenyl)acetamide
  • 1,1-Dimethoxy-5-methyl-4-(propan-2-yl)hexan-3-one
  • 1-Cyclopropyl-4-methoxypentane-1,3-dione
  • 1-(2-Methylpyridin-4-yl)cyclopropane-1-carbaldehyde
  • {2-Oxaspiro[4.7]dodecan-1-yl}methanesulfonamide
  • 6-Fluoro-5,7-dihydroxypyrazolo[1,5-a]pyrimidine-2-carboxylic acid
  • 2-methanesulfonyl-3-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)-3-oxopropanenitrile
  • 3-Ethoxy-1-(4-fluorophenyl)-2-methylprop-2-en-1-one
  • 1-cyclopentyl-3-(1-methyl-1H-pyrazol-5-yl)-4,5-dihydro-1H-pyrazol-5-one
  • 2-[(1s,3r)-1-(3,5-Dimethylphenyl)-3-fluorocyclobutyl]acetic acid
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