HEPARIN, SODIUM, LOW MOLECULAR WEIGHT

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Names

[ Name ]:
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT

[Synonym ]:
meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione)
2,6-Piperazinedione,4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-,rel
C12H18N4O4
2,6-Piperazinedione,4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-,(R*,S*)
2,6-Piperazinedione,4,4'-(1,2-dimethylethylene)di-,meso
AjvW2
ICRF-193

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₈N₄O₄

[ Molecular Weight ]:
282.30

[ Exact Mass ]:
282.13300

[ PSA ]:
105.80000

[ Vapour Pressure ]:
3.48E-11mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H317

[ Precautionary Statements ]:
P280-P301 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Risk Phrases ]:
22-43

[ Safety Phrases ]:
36/37

[ RIDADR ]:
UN 2811 6.1/PG 3

[ RTECS ]:
TL6380200

Articles

DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.

Mutat. Res. 530 , 35-46, (2003)

The bis-dioxopiperazine ICRF-193 has long time been considered as a pure topoisomerase II catalytic inhibitor able to exert its inhibitory effect on the enzyme without stabilization of the so-called c...

Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.

Biochem. Pharmacol. 57 , 1105, (1999)

As many antitumor drugs can kill tumors through the induction of apoptosis, the effect of these drugs presumably would be enhanced if they were used in combination with other drugs that interact with ...

Topoisomerase II poisoning by ICRF-193.

J. Biol. Chem. 276 , 44488-44494, (2001)

Antineoplastic bis(dioxopiperazine)s, such as meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane (ICRF-193), are widely believed to be only catalytic inhibitors of topoisomerase II. However, topoisomerase in...