HEPARIN, SODIUM, LOW MOLECULAR WEIGHT
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT structure
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Common Name | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT | ||
|---|---|---|---|---|
| CAS Number | 21416-88-6 | Molecular Weight | 282.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H18N4O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.
Mutat. Res. 530 , 35-46, (2003) The bis-dioxopiperazine ICRF-193 has long time been considered as a pure topoisomerase II catalytic inhibitor able to exert its inhibitory effect on the enzyme without stabilization of the so-called cleavable complex formed by DNA covalently bound to topoisom... |
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Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.
Biochem. Pharmacol. 57 , 1105, (1999) As many antitumor drugs can kill tumors through the induction of apoptosis, the effect of these drugs presumably would be enhanced if they were used in combination with other drugs that interact with apoptotic processes. To clarify the biological events invol... |
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Topoisomerase II poisoning by ICRF-193.
J. Biol. Chem. 276 , 44488-44494, (2001) Antineoplastic bis(dioxopiperazine)s, such as meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane (ICRF-193), are widely believed to be only catalytic inhibitors of topoisomerase II. However, topoisomerase inhibitors have little or no antineoplastic activity unless t... |
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ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase.
J. Biol. Chem. 277 , 36832, (2002) An ATR-dependent G(2) checkpoint responds to inhibition of topoisomerase II and delays entry into mitosis by sustaining nuclear exclusion of cyclin B1-Cdk1 complexes. Here we report that induction of this checkpoint with ICRF-193, a topoisomerase II catalytic... |
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The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.
Mol. Pharmacol. 59 , 453, (2001) The bisdioxopiperazines ICRF-187 (dexrazoxane), ICRF-193, and ICRF-154 are catalytic noncleavable complex-forming inhibitors of DNA topoisomerase II that do not produce protein-linked DNA strand breaks. In this study, we showed that bisdioxopiperazines induce... |