PYRONINE B

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Names

[ CAS No. ]:
2150-48-3

[ Name ]:
PYRONINE B

[Synonym ]:
Ethanaminium, N-[6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethyl-, chloride (1:1)
Ethanaminium, N-[6- (diethylamino)-3H-xanthen-3-ylidene]-N-ethyl-, chloride
Pyronine B,purified
E tetraethylpyronin
[6-(Diethylamino)-3H-xanthen-3-ylidene]diethylammonium chloride
3.6-Bis-diaethylamino-xanthylium-chlorid
Pyronin B
6-(Diethylamino)-N,N-diethyl-3H-xanthen-3-iminium chloride
MFCD00011932
Ammonium, [6- (diethylamino)-3H-xanthen-3-ylidene]diethyl-, chloride
EINECS 218-429-9
3,6-bis-diethylamino xanthylium chloride
PYRONINE B

Chemical & Physical Properties

[ Melting Point ]:
174-176ºC

[ Molecular Formula ]:
C21H27ClN2O

[ Molecular Weight ]:
358.905

[ Exact Mass ]:
358.181183

[ PSA ]:
19.39000

[ LogP ]:
1.19980

[ Appearance of Characters ]:
crystals | Green needles or

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
Soluble in water, ethyl acetate, methyl acetate, ethylene glycol; slightly soluble in ethanol, methanol, methyl cellosolve

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BP6832000
CHEMICAL NAME :
Ammonium, (6-(diethylamino)-3H-xanthen-3-ylidene)diethyl-, chloride
CAS REGISTRY NUMBER :
2150-48-3
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C21-H27-N2-O.Cl
MOLECULAR WEIGHT :
358.95
WISWESSER LINE NOTATION :
T C666 BO EYJ EUK2&2 MN2&2 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Insect - Drosophila melanogaster
DOSE/DURATION :
1000 ppm
REFERENCE :
AMNTA4 American Naturalist. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1867- Volume(issue)/page/year: 87,295,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3951 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 162 (estimated) No. of Female Employees: 124 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R68

[ Safety Phrases ]:
S22;S45;S24/25;S36/S37

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
BP6832000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-diethylamino-2-[(4-diethylamino-2-hydroxy-phenyl)methyl]phenol
  • Hydrochloric acid
  • Formic Acid
  • Glycerol
  • 3-(diethylamino)phenol

DownStream

Articles

Analysis and testing of biological stains--the Biological Stain Commission Procedures.

Biotech. Histochem. 77(5&6) , 237-275, (2002)

[Fluorescence investigation on interaction between artemisinin (qinghaosu) and hemin and its analytical application].

Guang Pu Xue Yu Guang Pu Fen Xi 26(9) , 1640-3, (2006)

Hemin-catalytic decomposition of artemisinin (qinghaosu, QHS) was studied using pyronine B (PB) as an indicator. The interaction between hemin and QHS was an enzyme-substrate model, and the action sit...

Nuclear dyes and cytoplasmic staining.

Cytometry 29(4) , 375-6, (1997)


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