Sodium Dichloroacetate
Suppliers
Names
[ CAS No. ]:
2156-56-1
[ Name ]:
Sodium Dichloroacetate
[Synonym ]:
Acetic acid, 2,2-dichloro-, sodium salt (1:1)
EINECS 218-461-3
MFCD00070489
Cpc 211
sodium salt of dichloroacetate
Sodium dichloroacetate [USAN]
Natriumdichloracetat
dichloroacetate de sodium
ACETIC ACID,DICHLORO-,SODIUM SALT
Sodium dichloroacetate
Dichloroctan sodny [Czech]
dichloroacetic acid sodium salt
sodium dichlroacetate
dichloroacetate sodium salt
Sodium 2,2-dichloroacetate
Chemical & Physical Properties
[ Boiling Point ]:
194ºC at 760mmHg
[ Melting Point ]:
198 °C (dec.)(lit.)
[ Molecular Formula ]:
C2HCl2NaO2
[ Molecular Weight ]:
150.924
[ Exact Mass ]:
149.925125
[ PSA ]:
40.13000
[ Vapour Pressure ]:
0.196mmHg at 25°C
[ Storage condition ]:
Desiccate at RT
[ Water Solubility ]:
soluble in cold water
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AG9275000
- CHEMICAL NAME :
- Acetic acid, dichloro-, sodium salt
- CAS REGISTRY NUMBER :
- 2156-56-1
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C2-H-Cl2-O2.Na
- MOLECULAR WEIGHT :
- 150.92
- WISWESSER LINE NOTATION :
- QVYGG &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5281 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4845 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30425 mg/kg/12W-C
- TOXIC EFFECTS :
- Brain and Coverings - changes in brain weight Endocrine - changes in adrenal weight Kidney, Ureter, Bladder - changes in bladder weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 45500 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - hypoglycemia Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2450 mg/kg/7W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 61 gm/kg/12W-C
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - recording from peripheral motor nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4550 mg/kg/13W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - food intake (animal) Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 164 gm/kg/1Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 182 gm/kg
- SEX/DURATION :
- male 13 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4375 mg/kg
- SEX/DURATION :
- male 10 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2188 mg/kg
- SEX/DURATION :
- male 10 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 5 ug/plate
- REFERENCE :
- AJCNAC American Journal of Clinical Nutrition. (American Soc. for Clinical Nutrition, Inc., 9650 Rockville Pike, Bethesda, MD 20814) V.2- 1954- Volume(issue)/page/year: 33,1179,1980
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335-H351
[ Precautionary Statements ]:
P261-P281-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
2811
[ WGK Germany ]:
2
[ RTECS ]:
AG9275000
[ HS Code ]:
2942000000
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2942000000
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