Fludarabine

Suppliers

Names

[ Name ]:
Fludarabine

[Synonym ]:
UNII-P2K93U8740
9-b-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
9-β-D-Arabinofuranosyl-2-fluoroadenine
MFCD00132942
9H-Purin-6-amine, 9-β-D-arabinofuranosyl-2-fluoro-
Fludarabine des-phosphate
9-(β-D-Arabinofuranosyl)-2-fluoro-9H-purin-6-amine
9-b-D-Arabinofuranosyl-2-fluoroadenine
(2R,3S,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Fludarabine
EINECS 244-525-5
2-Fluoro-9-b-D-arabinofuranosyladenine
F-Ara-A
2-Fluoroadenine-9-β-D-arabinofuranoside
2-F-araA
Adenine, 9-β-D-arabinofuranosyl-2-fluoro-
2-Fluorovidarabine

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
747.3±70.0 °C at 760 mmHg

[ Melting Point ]:
265-268ºC

[ Molecular Formula ]:
C₁₀H₁₂FN₅O₄

[ Molecular Weight ]:
285.232

[ Flash Point ]:
405.8±35.7 °C

[ Exact Mass ]:
285.087341

[ PSA ]:
139.54000

[ LogP ]:
-0.40

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.876

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMF: 20 mg/mL, clear, faintly yellow

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU6207000

CHEMICAL NAME :: Adenine, 9-beta-D-arabinofuranosyl-2-fluoro-

CAS REGISTRY NUMBER :: 21679-14-1

LAST UPDATED :: 198909

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H12-F-N5-O4

MOLECULAR WEIGHT :: 285.27

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ GF IZ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,291,1989

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R23/24/25;R36/37/38;R39

[ Safety Phrases ]:
S26-S36/37-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AU6207000

Articles

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Drug Metab. Dispos. 36 , 1385-405, (2008)

We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...