1-Methylguanidine hydrochloride
Suppliers
Names
[ CAS No. ]:
21770-81-0
[ Name ]:
1-Methylguanidine hydrochloride
[Synonym ]:
1-Methylguanidine hydrochloride
1-Methylguanidine HCl
2-methylguanidine hydrochloride
Methylguanidine HCl
Methylguanidinehydrochloride
MFCD00012576
Chemical & Physical Properties
[ Density]:
1.22 g/mL at 20 °C(lit.)
[ Boiling Point ]:
72 °C
[ Melting Point ]:
-20 °C
[ Molecular Formula ]:
C2H8ClN3
[ Molecular Weight ]:
109.55800
[ Flash Point ]:
65 °F
[ Exact Mass ]:
109.04100
[ PSA ]:
61.90000
[ LogP ]:
1.09220
[ Index of Refraction ]:
n20/D 1.4279(lit.)
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MF3990000
- CHEMICAL NAME :
- Guanidine, 1-methyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 21770-81-0
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C2-H7-N3.Cl-H
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 28,251,1926
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 680 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 1,434,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04013
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319
[ Precautionary Statements ]:
P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S26-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
MF3990000
Preparation
Articles
J. Pharm. Pharm. Sci. 17(4) , 475-84, (2015)
Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a majo...
J. Chem. Phys. 142 , 212436, (2015)
We study the interaction between the ions methylguanidinium and trifluoroacetate dissolved in D2O and dimethylsulfoxide with linear infrared spectroscopy and femtosecond two-dimensional infrared spect...
J. Pharm. Pharmacol. 67(2) , 170-7, (2015)
It has been reported that intestinal urate excretion is increased at chronic kidney disease (CKD) state. In this report, whether uremic toxins are involved in the upregulation of intestinal breast can...